Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis
Background: A growing number of countries implement prenatal pertussis vaccination policies to safeguard unvaccinated infants. This meta-analysis aimed to evaluate the efficacy, immunogenicity, and safety of antenatal Tdap vaccination in pregnant individuals. Methods: We systematically searched PubM...
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2025-06-01
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| author | Qianqian Shi Jun Li Quanman Hu Cheng Cheng Kun Yang Xiaoyu Li Xiaoru Song Shuaiyin Chen Guangcai Duan |
| author_facet | Qianqian Shi Jun Li Quanman Hu Cheng Cheng Kun Yang Xiaoyu Li Xiaoru Song Shuaiyin Chen Guangcai Duan |
| author_sort | Qianqian Shi |
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| description | Background: A growing number of countries implement prenatal pertussis vaccination policies to safeguard unvaccinated infants. This meta-analysis aimed to evaluate the efficacy, immunogenicity, and safety of antenatal Tdap vaccination in pregnant individuals. Methods: We systematically searched PubMed, Embase, and Web of Science from their inception to 16 February 2025, rigorously screening studies and including seven randomized controlled trials and 10 case-control studies published between 2014 and 2024. For the test-negative design meta-analysis, odds ratios with 95% confidence intervals served as effect estimates, and vaccine efficacy was calculated accordingly. Standardized mean differences were used to assess geometric mean concentrations, while relative risks evaluated safety. Results: Maternal vaccination during pregnancy demonstrated 85% vaccine effectiveness (95% CI: 78–89%) in protecting infants under 3 months old. Pooled standardized mean differences for cord blood IgG antibodies against pertussis toxin, pertactin, and filamentous hemagglutinin were 1.57 (95% CI: 1.25–1.89), 2.15 (95% CI: 1.82–2.48), and 2.25 (95% CI: 1.81–2.68), respectively, indicating higher antibody levels in infants of vaccinated women before their first immunization. Safety analysis showed no significant association between Tdap vaccination during pregnancy and serious adverse events in infants (RR = 0.76, 95% CI: 0.46–1.24) and pregnant women (RR = 1.22, 95% CI: 0.83–1.81). Conclusion: Our findings support the implementation of pertussis vaccination during pregnancy. |
| format | Article |
| id | doaj-art-ad42a20b1a3b4f3eb06532ce58e27efc |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-06-01 |
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| series | Vaccines |
| spelling | doaj-art-ad42a20b1a3b4f3eb06532ce58e27efc2025-08-20T03:32:35ZengMDPI AGVaccines2076-393X2025-06-0113766610.3390/vaccines13070666Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-AnalysisQianqian Shi0Jun Li1Quanman Hu2Cheng Cheng3Kun Yang4Xiaoyu Li5Xiaoru Song6Shuaiyin Chen7Guangcai Duan8Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaHenan Center for Disease Control and Prevention, Zhengzhou 450016, ChinaDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaHenan Cancer Hospital, Zhengzhou 450008, ChinaDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaBackground: A growing number of countries implement prenatal pertussis vaccination policies to safeguard unvaccinated infants. This meta-analysis aimed to evaluate the efficacy, immunogenicity, and safety of antenatal Tdap vaccination in pregnant individuals. Methods: We systematically searched PubMed, Embase, and Web of Science from their inception to 16 February 2025, rigorously screening studies and including seven randomized controlled trials and 10 case-control studies published between 2014 and 2024. For the test-negative design meta-analysis, odds ratios with 95% confidence intervals served as effect estimates, and vaccine efficacy was calculated accordingly. Standardized mean differences were used to assess geometric mean concentrations, while relative risks evaluated safety. Results: Maternal vaccination during pregnancy demonstrated 85% vaccine effectiveness (95% CI: 78–89%) in protecting infants under 3 months old. Pooled standardized mean differences for cord blood IgG antibodies against pertussis toxin, pertactin, and filamentous hemagglutinin were 1.57 (95% CI: 1.25–1.89), 2.15 (95% CI: 1.82–2.48), and 2.25 (95% CI: 1.81–2.68), respectively, indicating higher antibody levels in infants of vaccinated women before their first immunization. Safety analysis showed no significant association between Tdap vaccination during pregnancy and serious adverse events in infants (RR = 0.76, 95% CI: 0.46–1.24) and pregnant women (RR = 1.22, 95% CI: 0.83–1.81). Conclusion: Our findings support the implementation of pertussis vaccination during pregnancy.https://www.mdpi.com/2076-393X/13/7/666pregnancyinfantspertussis |
| spellingShingle | Qianqian Shi Jun Li Quanman Hu Cheng Cheng Kun Yang Xiaoyu Li Xiaoru Song Shuaiyin Chen Guangcai Duan Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis Vaccines pregnancy infants pertussis |
| title | Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis |
| title_full | Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis |
| title_fullStr | Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis |
| title_full_unstemmed | Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis |
| title_short | Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis |
| title_sort | efficacy immunogenicity and safety of pertussis vaccine during pregnancy a meta analysis |
| topic | pregnancy infants pertussis |
| url | https://www.mdpi.com/2076-393X/13/7/666 |
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