Genes Related to Motility in an Ionizing Radiation and Estrogen Breast Cancer Model
Breast cancer is a major global health concern as it is the primary cause of cancer death for women. Environmental radiation exposure and endogenous factors such as hormones increase breast cancer risk, and its development and spread depend on cell motility and migration. The expression of genes ass...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
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| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/13/11/849 |
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| Summary: | Breast cancer is a major global health concern as it is the primary cause of cancer death for women. Environmental radiation exposure and endogenous factors such as hormones increase breast cancer risk, and its development and spread depend on cell motility and migration. The expression of genes associated with cell motility, such as <i>ADAM12</i>, <i>CYR61</i>, <i>FLRT2</i>, <i>SLIT2</i>, <i>VNN1</i>, <i>MYLK</i>, <i>MAP1B</i>, and <i>TUBA1A</i>, was analyzed in an experimental breast cancer model induced by radiation and estrogen. The results showed that <i>TUBA1A</i>, <i>SLIT2</i>, <i>MAP1B</i>, <i>MYLK</i>, and <i>ADAM12</i> gene expression increased in the irradiated Alpha3 cell line but not in the control or the malignant Tumor2 cell line. Bioinformatic analysis indicated that <i>FLERT2</i>, <i>SLIT2</i>, <i>VNN1</i>, <i>MAP1B</i>, <i>MYLK</i>, and <i>TUBA1A</i> gene expressions were found to be higher in normal tissue than in tumor tissue of breast cancer patients. However, <i>ADAM12</i> and <i>CYR61</i> expressions were found to be higher in tumors than in normal tissues, and they had a negative correlation with <i>ESR1</i> gene expression. Concerning <i>ESR2</i> gene expression, there was a negative correlation with <i>CYR61</i>, but there was a positive correlation with <i>FLRT2</i>, <i>MYLK</i>, <i>MAP1B</i>, and <i>VNN1</i>. Finally, a decreased survival rate was observed in patients exhibiting high expression levels of <i>TUBA1A</i> and <i>MAP1B.</i> These genes also showed a negative ER status, an important parameter for endocrine therapy. The genes related to motility were affected by ionizing radiation, confirming its role in the initiation process of breast carcinogenesis. In conclusion, the relationship between the patient’s expression of hormone receptors and genes associated with cell motility presents a novel prospect for exploring therapeutic strategies. |
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| ISSN: | 2079-7737 |