Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4
Objectives To evaluate the Medical Research Council (MRC) dyspnoea scale and serum Microfibrillar-associated protein 4 (MFAP4) levels for the detection of respiratory impairment in newly diagnosed rheumatoid arthritis (RA).Methods Patients underwent blood tests, pulmonary function tests (PFT) and dy...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | European Clinical Respiratory Journal |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20018525.2024.2449270 |
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| author | Bjørk K. Sofiudottir Sören Möller Robin Christensen Stefan Harders Grith L. Sørensen Jesper Blegvad Mette Herly Dzenan Masic Grazina Urbonaviciene Frank Andersen Christin Isaksen Brian Bridal Løgstrup Charlotte Hyldgaard Torkell Ellingsen |
| author_facet | Bjørk K. Sofiudottir Sören Möller Robin Christensen Stefan Harders Grith L. Sørensen Jesper Blegvad Mette Herly Dzenan Masic Grazina Urbonaviciene Frank Andersen Christin Isaksen Brian Bridal Løgstrup Charlotte Hyldgaard Torkell Ellingsen |
| author_sort | Bjørk K. Sofiudottir |
| collection | DOAJ |
| description | Objectives To evaluate the Medical Research Council (MRC) dyspnoea scale and serum Microfibrillar-associated protein 4 (MFAP4) levels for the detection of respiratory impairment in newly diagnosed rheumatoid arthritis (RA).Methods Patients underwent blood tests, pulmonary function tests (PFT) and dyspnoea assessment using the MRC scale. Respiratory impairment was defined as a diffusion capacity of the lungs for carbon monoxide (DLCO) <80% predicted or FEV1/FVC <70%. The primary outcomes were the MRC and MFAP4’s sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals (CI).Results One hundred and thirty-one patients had available baseline tests. Mean age was 57.7 years (SD: 10.9), 61% were female, and 45% had respiratory impairment. For MRC score ≥ 2, the sensitivity was 39.0% (95% CI 26.5; 52.6), specificity 76.4% (95% CI 64.9; 85.6), and DOR 2.07 (95% CI 0.97; 4.40). For MFAP4 > 29.0 U/mL, the sensitivity was 62.7% (95% CI 49.1; 75.0), specificity 56.9% (95% CI 44.7; 68.6), and DOR 2.22 (95% CI 1.10; 4.50). The DOR was 3.01 (95% CI 1.27; 7.16) for MFAP4 detecting respiratory impairment when adjusted for age, sex and smoking status.Conclusion The MRC dyspnoea score and unadjusted MFAP4 levels were poor predictors of respiratory impairment in patients with early treatment-naïve rheumatoid arthritis. |
| format | Article |
| id | doaj-art-ad3fd4334fa54466b03c8e3a1a3e75c9 |
| institution | Kabale University |
| issn | 2001-8525 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Clinical Respiratory Journal |
| spelling | doaj-art-ad3fd4334fa54466b03c8e3a1a3e75c92025-01-18T01:16:20ZengTaylor & Francis GroupEuropean Clinical Respiratory Journal2001-85252025-12-0112110.1080/20018525.2024.2449270Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4Bjørk K. Sofiudottir0Sören Möller1Robin Christensen2Stefan Harders3Grith L. Sørensen4Jesper Blegvad5Mette Herly6Dzenan Masic7Grazina Urbonaviciene8Frank Andersen9Christin Isaksen10Brian Bridal Løgstrup11Charlotte Hyldgaard12Torkell Ellingsen13Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark & Odense University Hospital, Odense, DenmarkOPEN – Open Patient Data Explorative Network, Odense University Hospital, Odense, DenmarkResearch Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark & Odense University Hospital, Odense, DenmarkThe Department of Radiology, Aarhus University Hospital, Aarhus, DenmarkThe Department of Molecular Medicine, University of Southern Denmark, Odense, DenmarkDiagnostic Center, Silkeborg Regional Hospital, University Clinic for Innovative Patient Pathways, Silkeborg, DenmarkResearch Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark & Odense University Hospital, Odense, DenmarkResearch Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark & Odense University Hospital, Odense, DenmarkDiagnostic Center, Silkeborg Regional Hospital, University Clinic for Innovative Patient Pathways, Silkeborg, DenmarkDiagnostic Center, Silkeborg Regional Hospital, University Clinic for Innovative Patient Pathways, Silkeborg, DenmarkDiagnostic Center, Silkeborg Regional Hospital, University Clinic for Innovative Patient Pathways, Silkeborg, DenmarkDiagnostic Center, Silkeborg Regional Hospital, University Clinic for Innovative Patient Pathways, Silkeborg, DenmarkDiagnostic Center, Silkeborg Regional Hospital, University Clinic for Innovative Patient Pathways, Silkeborg, DenmarkResearch Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark & Odense University Hospital, Odense, DenmarkObjectives To evaluate the Medical Research Council (MRC) dyspnoea scale and serum Microfibrillar-associated protein 4 (MFAP4) levels for the detection of respiratory impairment in newly diagnosed rheumatoid arthritis (RA).Methods Patients underwent blood tests, pulmonary function tests (PFT) and dyspnoea assessment using the MRC scale. Respiratory impairment was defined as a diffusion capacity of the lungs for carbon monoxide (DLCO) <80% predicted or FEV1/FVC <70%. The primary outcomes were the MRC and MFAP4’s sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals (CI).Results One hundred and thirty-one patients had available baseline tests. Mean age was 57.7 years (SD: 10.9), 61% were female, and 45% had respiratory impairment. For MRC score ≥ 2, the sensitivity was 39.0% (95% CI 26.5; 52.6), specificity 76.4% (95% CI 64.9; 85.6), and DOR 2.07 (95% CI 0.97; 4.40). For MFAP4 > 29.0 U/mL, the sensitivity was 62.7% (95% CI 49.1; 75.0), specificity 56.9% (95% CI 44.7; 68.6), and DOR 2.22 (95% CI 1.10; 4.50). The DOR was 3.01 (95% CI 1.27; 7.16) for MFAP4 detecting respiratory impairment when adjusted for age, sex and smoking status.Conclusion The MRC dyspnoea score and unadjusted MFAP4 levels were poor predictors of respiratory impairment in patients with early treatment-naïve rheumatoid arthritis.https://www.tandfonline.com/doi/10.1080/20018525.2024.2449270Rheumatoid arthritisrespiratory impairmentMRCMFAP4Early detection |
| spellingShingle | Bjørk K. Sofiudottir Sören Möller Robin Christensen Stefan Harders Grith L. Sørensen Jesper Blegvad Mette Herly Dzenan Masic Grazina Urbonaviciene Frank Andersen Christin Isaksen Brian Bridal Løgstrup Charlotte Hyldgaard Torkell Ellingsen Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4 European Clinical Respiratory Journal Rheumatoid arthritis respiratory impairment MRC MFAP4 Early detection |
| title | Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4 |
| title_full | Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4 |
| title_fullStr | Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4 |
| title_full_unstemmed | Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4 |
| title_short | Detecting respiratory impairment in newly diagnosed rheumatoid arthritis by MRC dyspnoea scale and microfibrillar-associated protein 4 |
| title_sort | detecting respiratory impairment in newly diagnosed rheumatoid arthritis by mrc dyspnoea scale and microfibrillar associated protein 4 |
| topic | Rheumatoid arthritis respiratory impairment MRC MFAP4 Early detection |
| url | https://www.tandfonline.com/doi/10.1080/20018525.2024.2449270 |
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