Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh
Type 2 diabetes mellitus (T2DM) is a global health concern, particularly prevalent in low to middle-income countries like Bangladesh. This case-control study aims to explore the correlation between the ADIPOQ rs1501299 polymorphism and susceptibility to T2DM among the population of Noakhali region o...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/genr/8818420 |
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| author | Md. Anamul Haque Md. Sad Salabi Sawrav Shipan Das Gupta Shuvo Chandra Das Dhirendra Nath Barman Mohammed Mafizul Islam Md. Murad Hossain |
| author_facet | Md. Anamul Haque Md. Sad Salabi Sawrav Shipan Das Gupta Shuvo Chandra Das Dhirendra Nath Barman Mohammed Mafizul Islam Md. Murad Hossain |
| author_sort | Md. Anamul Haque |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is a global health concern, particularly prevalent in low to middle-income countries like Bangladesh. This case-control study aims to explore the correlation between the ADIPOQ rs1501299 polymorphism and susceptibility to T2DM among the population of Noakhali region of Bangladesh. The study, involving 152 T2DM patients and 118 healthy controls, explores the genetic underpinnings of T2DM, considering the rising prevalence in Bangladesh. The ADIPOQ gene, implicated in diabetes development, is examined for the rs1501299 polymorphism, known for its associations with insulin resistance and T2DM in various populations. Genotyping, conducted through PCR and RFLP analysis, reveals significant deviations from Hardy–Weinberg equilibrium for the TT genotype, suggesting potential demographic influences. Clinical and biochemical characteristics, including blood pressure and lipid levels, highlight the complex interplay between genetics, metabolic outcomes and cardiovascular health in T2DM patients. This study identifies a significant association between the ADIPOQ rs1501299 T allele and increased T2DM risk, emphasizing the need for personalized risk assessment. However, ADIPOQ rs1501299 did not show any substantial association with CVD in the studied population. Despite limitations in sample size and regional focus, this study provides valuable insights into the genetic landscape of T2DM in the Noakhali population, paving the way for future research and personalized therapeutic interventions in addressing the global T2DM epidemic. |
| format | Article |
| id | doaj-art-ad39ffd5ba6849d5a25c044980f2bdc9 |
| institution | OA Journals |
| issn | 1469-5073 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-ad39ffd5ba6849d5a25c044980f2bdc92025-08-20T02:17:32ZengWileyGenetics Research1469-50732025-01-01202510.1155/genr/8818420Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of BangladeshMd. Anamul Haque0Md. Sad Salabi Sawrav1Shipan Das Gupta2Shuvo Chandra Das3Dhirendra Nath Barman4Mohammed Mafizul Islam5Md. Murad Hossain6Department of Biotechnology and Genetic EngineeringDepartment of Biotechnology and Genetic EngineeringDepartment of Biotechnology and Genetic EngineeringDepartment of Biotechnology and Genetic EngineeringDepartment of Biotechnology and Genetic EngineeringDepartment of Biotechnology and Genetic EngineeringDepartment of Biotechnology and Genetic EngineeringType 2 diabetes mellitus (T2DM) is a global health concern, particularly prevalent in low to middle-income countries like Bangladesh. This case-control study aims to explore the correlation between the ADIPOQ rs1501299 polymorphism and susceptibility to T2DM among the population of Noakhali region of Bangladesh. The study, involving 152 T2DM patients and 118 healthy controls, explores the genetic underpinnings of T2DM, considering the rising prevalence in Bangladesh. The ADIPOQ gene, implicated in diabetes development, is examined for the rs1501299 polymorphism, known for its associations with insulin resistance and T2DM in various populations. Genotyping, conducted through PCR and RFLP analysis, reveals significant deviations from Hardy–Weinberg equilibrium for the TT genotype, suggesting potential demographic influences. Clinical and biochemical characteristics, including blood pressure and lipid levels, highlight the complex interplay between genetics, metabolic outcomes and cardiovascular health in T2DM patients. This study identifies a significant association between the ADIPOQ rs1501299 T allele and increased T2DM risk, emphasizing the need for personalized risk assessment. However, ADIPOQ rs1501299 did not show any substantial association with CVD in the studied population. Despite limitations in sample size and regional focus, this study provides valuable insights into the genetic landscape of T2DM in the Noakhali population, paving the way for future research and personalized therapeutic interventions in addressing the global T2DM epidemic.http://dx.doi.org/10.1155/genr/8818420 |
| spellingShingle | Md. Anamul Haque Md. Sad Salabi Sawrav Shipan Das Gupta Shuvo Chandra Das Dhirendra Nath Barman Mohammed Mafizul Islam Md. Murad Hossain Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh Genetics Research |
| title | Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh |
| title_full | Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh |
| title_fullStr | Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh |
| title_full_unstemmed | Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh |
| title_short | Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh |
| title_sort | genetic insights into type 2 diabetes mellitus susceptibility a case control study of the adipoq rs1501299 polymorphism in the population of noakhali region of bangladesh |
| url | http://dx.doi.org/10.1155/genr/8818420 |
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