Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysis
This study aimed to optimize the extraction conditions of total polyphenols, flavonoid contents, and DPPH-IC50 from the stem part of Moroccan cannabis via a multidimensional approach. The response surface methodology and Box–Behnken design were used for the optimization based on sonication time, tem...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Case Studies in Chemical and Environmental Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666016424003001 |
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| author | Maryem El Oihabi Mohammed Soultana Imad El Fellah Hajar Fakih Lanjri Laïla Ben Allal Mohammed Ammari Asmaa Fakih Lanjri |
| author_facet | Maryem El Oihabi Mohammed Soultana Imad El Fellah Hajar Fakih Lanjri Laïla Ben Allal Mohammed Ammari Asmaa Fakih Lanjri |
| author_sort | Maryem El Oihabi |
| collection | DOAJ |
| description | This study aimed to optimize the extraction conditions of total polyphenols, flavonoid contents, and DPPH-IC50 from the stem part of Moroccan cannabis via a multidimensional approach. The response surface methodology and Box–Behnken design were used for the optimization based on sonication time, temperature, and ethanol concentration. Results showed that optimal response values were 125 mg GAE/g for TPC, 81 mg QEq/g for TFC, and 17 μg/mL for DPPH-IC50. This study presents new data on the quantity of chemicals in the stem of Cannabis depending on extraction conditions, which is very important in the valorization of this green material. The established conditions provide a foundational framework for real-world applications in the extraction of bioactive compounds from Cannabis stems and other vegetal materials. However, more investigations are needed to identify the molecules in the optimized extract. |
| format | Article |
| id | doaj-art-ad38cd0f7b3144ccb65fbfd329165350 |
| institution | OA Journals |
| issn | 2666-0164 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Studies in Chemical and Environmental Engineering |
| spelling | doaj-art-ad38cd0f7b3144ccb65fbfd3291653502025-08-20T02:17:57ZengElsevierCase Studies in Chemical and Environmental Engineering2666-01642024-12-011010090610.1016/j.cscee.2024.100906Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysisMaryem El Oihabi0Mohammed Soultana1Imad El Fellah2Hajar Fakih Lanjri3Laïla Ben Allal4Mohammed Ammari5Asmaa Fakih Lanjri6Corresponding author.; Research Team Materials, Environment and Sustainable Development, FSTT, Abdelmalek Essaadi University, Tetouan 93000, MoroccoResearch Team Materials, Environment and Sustainable Development, FSTT, Abdelmalek Essaadi University, Tetouan 93000, MoroccoResearch Team Materials, Environment and Sustainable Development, FSTT, Abdelmalek Essaadi University, Tetouan 93000, MoroccoResearch Team Materials, Environment and Sustainable Development, FSTT, Abdelmalek Essaadi University, Tetouan 93000, MoroccoResearch Team Materials, Environment and Sustainable Development, FSTT, Abdelmalek Essaadi University, Tetouan 93000, MoroccoResearch Team Materials, Environment and Sustainable Development, FSTT, Abdelmalek Essaadi University, Tetouan 93000, MoroccoResearch Team Materials, Environment and Sustainable Development, FSTT, Abdelmalek Essaadi University, Tetouan 93000, MoroccoThis study aimed to optimize the extraction conditions of total polyphenols, flavonoid contents, and DPPH-IC50 from the stem part of Moroccan cannabis via a multidimensional approach. The response surface methodology and Box–Behnken design were used for the optimization based on sonication time, temperature, and ethanol concentration. Results showed that optimal response values were 125 mg GAE/g for TPC, 81 mg QEq/g for TFC, and 17 μg/mL for DPPH-IC50. This study presents new data on the quantity of chemicals in the stem of Cannabis depending on extraction conditions, which is very important in the valorization of this green material. The established conditions provide a foundational framework for real-world applications in the extraction of bioactive compounds from Cannabis stems and other vegetal materials. However, more investigations are needed to identify the molecules in the optimized extract.http://www.sciencedirect.com/science/article/pii/S2666016424003001Cannabis stemBioactive compoundsUltrasound-assisted extractionBox–behnken designSensitivity analysisWaste valorization |
| spellingShingle | Maryem El Oihabi Mohammed Soultana Imad El Fellah Hajar Fakih Lanjri Laïla Ben Allal Mohammed Ammari Asmaa Fakih Lanjri Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysis Case Studies in Chemical and Environmental Engineering Cannabis stem Bioactive compounds Ultrasound-assisted extraction Box–behnken design Sensitivity analysis Waste valorization |
| title | Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysis |
| title_full | Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysis |
| title_fullStr | Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysis |
| title_full_unstemmed | Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysis |
| title_short | Optimized extraction of phenolic compounds and antioxidant activity from cannabis Co-products via a combination of solvent-ultrasound-assisted extraction, response surface methodology, and sensitivity analysis |
| title_sort | optimized extraction of phenolic compounds and antioxidant activity from cannabis co products via a combination of solvent ultrasound assisted extraction response surface methodology and sensitivity analysis |
| topic | Cannabis stem Bioactive compounds Ultrasound-assisted extraction Box–behnken design Sensitivity analysis Waste valorization |
| url | http://www.sciencedirect.com/science/article/pii/S2666016424003001 |
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