Intratumoral delivery of mRNA encoding the endogenous TLR2/6 agonist UNE-C1 induces immunogenic cell death and enhances antitumor activity

Intratumoral delivery of mRNA encoding the endogenous TLR2/6 agonist UNE-C1 induces immunogenic cell death and enhances antitumor activity

IntroductionRecent investigations have highlighted the intratumoral administration of Toll-like receptor (TLR) ligands as a promising approach to initiate localized immune responses and enhance antitumor immunity. However, the clinical application of these ligands is limited by their rapid dissemina...

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Main Authors: Uijoo Kim, Sunkyo Hwang, Seongmin Cho, Hyeong Yun Kim, Hamin Ban, Joohee Park, Jeongwon Mun, Nayoung Kim, Ji Hun Suh, Jihye Choi, Yungyeong Shin, Sang Bum Kim, Ina Yoon, Hyuk-Sang Kwon, Sunghoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
toll-like receptor
intratumoral treatment
mRNA therapeutics
tumor microenvironment
immunogenic cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1454504/full
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