Clinical validation of an integrated risk assessment test incorporating genomic and non-genomic data for sporadic breast cancer in Colombia

Clinical validation of an integrated risk assessment test incorporating genomic and non-genomic data for sporadic breast cancer in Colombia

IntroductionBreast cancer risk arises from a complex interaction of genetic, environmental, and physiological factors. Integrating Polygenic Risk Scores (PRS) with clinical risk factors can enhance personalized risk prediction, especially in diverse populations like Colombia.ObjectiveTo evaluate the...

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Main Authors: Harvy Mauricio Velasco Parra, Danny Styvens Cardona, Cesar Augusto Buitrago, Melisa Naranjo Vanegas, Sebastián Gutiérrez Hincapié, Carolina Jaramillo Jaramillo, Alicia Maria Cock-Rada, Carolina Benavides Duque, Clara Patricia Piedrahita, Catalina Bustamante, Leonel Andrés González Niño, Jen Kintle, Scott Kulm, Alessandro Bolli, Paolo Di Dominico, Giordano Botta, George B. Busby, Juan Pablo Valencia-Arango
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Genetics
Subjects:
polygenic risk score
breast cancer
risk stratification
prediction
epidemiology
Colombia
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1556907/full
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