Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension
Objective. To safety of NSAlDs concerning their prohypertensive effect and to devise tactics of management of pts with osteoarthritis and concomitant hypertension. Material and Methods. 98 pts with gonarthrosis and coxarthrosis of stage II-III with pain syndrome and concomitant hypertension of stage...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2004-02-01
|
| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1232 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849240320252837888 |
|---|---|
| author | L B Lasebnik O B Kotsubinskaya Y V Konev V N Drosdov |
| author_facet | L B Lasebnik O B Kotsubinskaya Y V Konev V N Drosdov |
| author_sort | L B Lasebnik |
| collection | DOAJ |
| description | Objective. To safety of NSAlDs concerning their prohypertensive effect and to devise tactics of management of pts with osteoarthritis and concomitant hypertension. Material and Methods. 98 pts with gonarthrosis and coxarthrosis of stage II-III with pain syndrome and concomitant hypertension of stage 1-II.Diclofenac, ketoprofen, arthrotec and meloxicam were administered. Control group pts received tramal in addition to the treatment. Hypertension was conlrolled with enalapril monotherapy. Results. Groups treated with diclofenac, atrhrotec, meloxicam and ketoprofen showed a tendency to deminution of number of pis with normal decrease of blood pressure (BP) in night hours ("Dipper") and increase of number of pts with insufficient BP nighl fall ("Non-dipper"). These changes may be connected with prohypertensive effect of these drogs. This tendency was more prominent in groups treated with diclofenac and arthrotec. Nimesulid inspite of its marked prohypertensive effect did not impair circadian rhythm of BP. Central analgesic tramal did not possess prohypertensive effect and did not increase BP. Conclusion. According to increase of prohypertensive effect study NSAlDs can be arranged as follows: tramadol, ketoprofen. meloxicam. nimesulid, arthrotec, diclofenac. |
| format | Article |
| id | doaj-art-ad1e6ed5d4734c70adbc54311c5f8d51 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2004-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-ad1e6ed5d4734c70adbc54311c5f8d512025-08-20T04:00:39ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922004-02-01421283310.14412/1995-4484-2004-13791172Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertensionL B LasebnikO B KotsubinskayaY V KonevV N DrosdovObjective. To safety of NSAlDs concerning their prohypertensive effect and to devise tactics of management of pts with osteoarthritis and concomitant hypertension. Material and Methods. 98 pts with gonarthrosis and coxarthrosis of stage II-III with pain syndrome and concomitant hypertension of stage 1-II.Diclofenac, ketoprofen, arthrotec and meloxicam were administered. Control group pts received tramal in addition to the treatment. Hypertension was conlrolled with enalapril monotherapy. Results. Groups treated with diclofenac, atrhrotec, meloxicam and ketoprofen showed a tendency to deminution of number of pis with normal decrease of blood pressure (BP) in night hours ("Dipper") and increase of number of pts with insufficient BP nighl fall ("Non-dipper"). These changes may be connected with prohypertensive effect of these drogs. This tendency was more prominent in groups treated with diclofenac and arthrotec. Nimesulid inspite of its marked prohypertensive effect did not impair circadian rhythm of BP. Central analgesic tramal did not possess prohypertensive effect and did not increase BP. Conclusion. According to increase of prohypertensive effect study NSAlDs can be arranged as follows: tramadol, ketoprofen. meloxicam. nimesulid, arthrotec, diclofenac.https://rsp.mediar-press.net/rsp/article/view/1232osteoarthritisnsajdiruirwlhypertension |
| spellingShingle | L B Lasebnik O B Kotsubinskaya Y V Konev V N Drosdov Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension Научно-практическая ревматология osteoarthritis nsajd iruirwl hypertension |
| title | Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension |
| title_full | Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension |
| title_fullStr | Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension |
| title_full_unstemmed | Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension |
| title_short | Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension |
| title_sort | effect of nonsteroidal anti inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension |
| topic | osteoarthritis nsajd iruirwl hypertension |
| url | https://rsp.mediar-press.net/rsp/article/view/1232 |
| work_keys_str_mv | AT lblasebnik effectofnonsteroidalantiinflammatorydrugsandtramalonbloodpressurelevelduringosteoarthritistreatmentinpatientswithhypertension AT obkotsubinskaya effectofnonsteroidalantiinflammatorydrugsandtramalonbloodpressurelevelduringosteoarthritistreatmentinpatientswithhypertension AT yvkonev effectofnonsteroidalantiinflammatorydrugsandtramalonbloodpressurelevelduringosteoarthritistreatmentinpatientswithhypertension AT vndrosdov effectofnonsteroidalantiinflammatorydrugsandtramalonbloodpressurelevelduringosteoarthritistreatmentinpatientswithhypertension |