Recent advances in the systemic treatment of gastrointestinal malignancy
In the following article, practice changing updates on gastrointestinal cancers management have been discussed. For metastatic colorectal cancer with RAS wild-type, fluoropyrimidine plus panitumumab combination has been the preferred maintenance option for patients who have stopped oxaliplatin. The...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=3;spage=336;epage=340;aulast=Paluri |
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| _version_ | 1849766531005677568 |
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| author | Ravi Kumar Paluri Rojymon Jacob Anup Kasi |
| author_facet | Ravi Kumar Paluri Rojymon Jacob Anup Kasi |
| author_sort | Ravi Kumar Paluri |
| collection | DOAJ |
| description | In the following article, practice changing updates on gastrointestinal cancers management have been discussed. For metastatic colorectal cancer with RAS wild-type, fluoropyrimidine plus panitumumab combination has been the preferred maintenance option for patients who have stopped oxaliplatin. The cytoreductive surgery alone showed satisfactory survival outcomes in colorectal cancer patients with peritoneal carcinomatosis. Dose escalation of regorafenib showed better clinical outcomes than the standard dosing regimen. Adjuvant FOLFIRINOX is the new treatment option for selected resected pancreatic cancer patients. Neoadjuvant treatment is the new paradigm for borderline and resectable pancreatic cancer patients. Several options for advanced hepatocellular cancers now available and more clinical studies are required for optimal treatment sequencing. Trifluridine/tipiracil showed improved overall survival in esophageal cancers beyond the second line. |
| format | Article |
| id | doaj-art-ad1d350dcdcc44d7b218f3f4bb6ecdf4 |
| institution | DOAJ |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-ad1d350dcdcc44d7b218f3f4bb6ecdf42025-08-20T03:04:31ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292019-01-0140333634010.4103/ijmpo.ijmpo_47_19Recent advances in the systemic treatment of gastrointestinal malignancyRavi Kumar PaluriRojymon JacobAnup KasiIn the following article, practice changing updates on gastrointestinal cancers management have been discussed. For metastatic colorectal cancer with RAS wild-type, fluoropyrimidine plus panitumumab combination has been the preferred maintenance option for patients who have stopped oxaliplatin. The cytoreductive surgery alone showed satisfactory survival outcomes in colorectal cancer patients with peritoneal carcinomatosis. Dose escalation of regorafenib showed better clinical outcomes than the standard dosing regimen. Adjuvant FOLFIRINOX is the new treatment option for selected resected pancreatic cancer patients. Neoadjuvant treatment is the new paradigm for borderline and resectable pancreatic cancer patients. Several options for advanced hepatocellular cancers now available and more clinical studies are required for optimal treatment sequencing. Trifluridine/tipiracil showed improved overall survival in esophageal cancers beyond the second line.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=3;spage=336;epage=340;aulast=Palurigastricgastrointestinal malignancypancreatic |
| spellingShingle | Ravi Kumar Paluri Rojymon Jacob Anup Kasi Recent advances in the systemic treatment of gastrointestinal malignancy Indian Journal of Medical and Paediatric Oncology gastric gastrointestinal malignancy pancreatic |
| title | Recent advances in the systemic treatment of gastrointestinal malignancy |
| title_full | Recent advances in the systemic treatment of gastrointestinal malignancy |
| title_fullStr | Recent advances in the systemic treatment of gastrointestinal malignancy |
| title_full_unstemmed | Recent advances in the systemic treatment of gastrointestinal malignancy |
| title_short | Recent advances in the systemic treatment of gastrointestinal malignancy |
| title_sort | recent advances in the systemic treatment of gastrointestinal malignancy |
| topic | gastric gastrointestinal malignancy pancreatic |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=3;spage=336;epage=340;aulast=Paluri |
| work_keys_str_mv | AT ravikumarpaluri recentadvancesinthesystemictreatmentofgastrointestinalmalignancy AT rojymonjacob recentadvancesinthesystemictreatmentofgastrointestinalmalignancy AT anupkasi recentadvancesinthesystemictreatmentofgastrointestinalmalignancy |