Using Human iPSC-Derived Neurons to Model TAU Aggregation.

Using Human iPSC-Derived Neurons to Model TAU Aggregation.

Alzheimer's disease and frontotemporal dementia are amongst the most common forms of dementia characterized by the formation and deposition of abnormal TAU in the brain. In order to develop a translational human TAU aggregation model suitable for screening, we transduced TAU harboring the pro-a...

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Main Authors: An Verheyen, Annick Diels, Joyce Dijkmans, Tutu Oyelami, Giulia Meneghello, Liesbeth Mertens, Sofie Versweyveld, Marianne Borgers, Arjan Buist, Pieter Peeters, Miroslav Cik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0146127
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