Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review
Introduction: The thymus gland plays a pivotal role in immune system regulation, but conditions such as thymic hyperplasia (TH) and thymoma pose distinct clinical challenges due to their rarity and complex presentation in surgical practice. Both conditions can mimic similar symptoms, particularly i...
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Albanian Society for Trauma and Emergency Surgery
2025-01-01
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| Series: | Albanian Journal of Trauma and Emergency Surgery |
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| Online Access: | http://journal.astes.org.al/AJTES/index.php/AJTES/article/view/428 |
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| author | Selman Dumani Altin Kuqo Ermal Likaj Saimir Kuci Majlinda Ikonomi Laureta Dibra Alessia Mehmeti Ejona Celiku Altin Veshti |
| author_facet | Selman Dumani Altin Kuqo Ermal Likaj Saimir Kuci Majlinda Ikonomi Laureta Dibra Alessia Mehmeti Ejona Celiku Altin Veshti |
| author_sort | Selman Dumani |
| collection | DOAJ |
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Introduction: The thymus gland plays a pivotal role in immune system regulation, but conditions such as thymic hyperplasia (TH) and thymoma pose distinct clinical challenges due to their rarity and complex presentation in surgical practice. Both conditions can mimic similar symptoms, particularly in patients with Myasthenia Gravis (MG), where surgery serves as both a diagnostic and therapeutic intervention. This report presents the surgical management and outcomes of two MG patients with distinct thymic pathologies: TH and Type B thymoma, alongside a review of the relevant literature.
Two MG patients were referred to our clinic for surgical intervention. The first patient underwent a standard sternotomy for the resection of TH, while the second patient underwent a mini-sternotomy for thymectomy targeting a Type B thymoma. Both procedures were completed successfully with uneventful postoperative courses. Surgical resection remains the gold standard for the treatment and definitive diagnosis of thymic gland abnormalities. Advances in surgical techniques, including minimally invasive approaches, offer excellent outcomes with reduced morbidity, providing a viable alternative to traditional methods.
Conclusion: The cases underscore the critical role of surgical intervention in managing thymic pathologies in MG patients. Both traditional and minimally invasive techniques yield excellent clinical outcomes, reinforcing their importance in the treatment paradigm for thymic hyperplasia and thymoma. Further studies are needed to refine surgical approaches and optimize patient outcomes.
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| format | Article |
| id | doaj-art-ad18c53ff7f24fc0996f792c3f3ae329 |
| institution | Kabale University |
| issn | 2521-8778 2616-4922 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Albanian Society for Trauma and Emergency Surgery |
| record_format | Article |
| series | Albanian Journal of Trauma and Emergency Surgery |
| spelling | doaj-art-ad18c53ff7f24fc0996f792c3f3ae3292025-01-19T14:24:40ZengAlbanian Society for Trauma and Emergency SurgeryAlbanian Journal of Trauma and Emergency Surgery2521-87782616-49222025-01-019110.32391/ajtes.v9i1.428Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature ReviewSelman Dumani0Altin Kuqo1Ermal Likaj2Saimir Kuci3Majlinda Ikonomi4Laureta Dibra5Alessia Mehmeti6Ejona Celiku7Altin Veshti8Service of Cardiac Surgery, University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Neurology¸ University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Cardiac Surgery, University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Cardiac Surgery, University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Pathological Anatomy¸ University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Cardiac Surgery, University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Cardiac Surgery, University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Pathological Anatomy¸ University Hospital Center” Mother Theresa”, Tirana, AlbaniaService of Cardiac Surgery, University Hospital Center” Mother Theresa”, Tirana, Albania Introduction: The thymus gland plays a pivotal role in immune system regulation, but conditions such as thymic hyperplasia (TH) and thymoma pose distinct clinical challenges due to their rarity and complex presentation in surgical practice. Both conditions can mimic similar symptoms, particularly in patients with Myasthenia Gravis (MG), where surgery serves as both a diagnostic and therapeutic intervention. This report presents the surgical management and outcomes of two MG patients with distinct thymic pathologies: TH and Type B thymoma, alongside a review of the relevant literature. Two MG patients were referred to our clinic for surgical intervention. The first patient underwent a standard sternotomy for the resection of TH, while the second patient underwent a mini-sternotomy for thymectomy targeting a Type B thymoma. Both procedures were completed successfully with uneventful postoperative courses. Surgical resection remains the gold standard for the treatment and definitive diagnosis of thymic gland abnormalities. Advances in surgical techniques, including minimally invasive approaches, offer excellent outcomes with reduced morbidity, providing a viable alternative to traditional methods. Conclusion: The cases underscore the critical role of surgical intervention in managing thymic pathologies in MG patients. Both traditional and minimally invasive techniques yield excellent clinical outcomes, reinforcing their importance in the treatment paradigm for thymic hyperplasia and thymoma. Further studies are needed to refine surgical approaches and optimize patient outcomes. http://journal.astes.org.al/AJTES/index.php/AJTES/article/view/428ThymomaThymic HyperplasiaMyasthenia GravisSurgical ResectionMinimally Invasive Surgery |
| spellingShingle | Selman Dumani Altin Kuqo Ermal Likaj Saimir Kuci Majlinda Ikonomi Laureta Dibra Alessia Mehmeti Ejona Celiku Altin Veshti Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review Albanian Journal of Trauma and Emergency Surgery Thymoma Thymic Hyperplasia Myasthenia Gravis Surgical Resection Minimally Invasive Surgery |
| title | Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review |
| title_full | Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review |
| title_fullStr | Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review |
| title_full_unstemmed | Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review |
| title_short | Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review |
| title_sort | thymus hyperplasia and thymoma type b in patients with myasthenia gravis two case reports and literature review |
| topic | Thymoma Thymic Hyperplasia Myasthenia Gravis Surgical Resection Minimally Invasive Surgery |
| url | http://journal.astes.org.al/AJTES/index.php/AJTES/article/view/428 |
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