N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease
IntroductionAnti-synthetase syndrome (ASS) is a subtype of idiopathic inflammatory myopathy (IIM) characterized by characteristic rash, myositis, and interstitial lung disease (ILD). The etiology of ASS is unknown, and patients have a poor quality of life and are prone to pulmonary infection. Recent...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538219/full |
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| author | Jing Zhao Yanhong Li Yingying Ling Tong Wu Yinlan Wu Chunyu Tan Lu Cheng Deying Huang Yi Liu Yong Zhang |
| author_facet | Jing Zhao Yanhong Li Yingying Ling Tong Wu Yinlan Wu Chunyu Tan Lu Cheng Deying Huang Yi Liu Yong Zhang |
| author_sort | Jing Zhao |
| collection | DOAJ |
| description | IntroductionAnti-synthetase syndrome (ASS) is a subtype of idiopathic inflammatory myopathy (IIM) characterized by characteristic rash, myositis, and interstitial lung disease (ILD). The etiology of ASS is unknown, and patients have a poor quality of life and are prone to pulmonary infection. Recent studies have elucidated the potential role of abnormal glycosylation of immunoglobulin G (IgG) in the pathogenesis of autoimmune diseases. However, the pattern of patient-specific IgG N-glycosylation in ASS has not been fully elucidated.Methodsthe GlycoQuant method was used to quantify the intact N-glycopeptides of IgG from 30 ASS patients and 30 healthy controls (HCs). Results and DiscussionThirteen differentially expressed intact N-glycopeptides were identified (p<0.05). Notably, we observed increased fucosylation (p<0.0001) and decreased N-acetylneuraminic acid (p<0.05) in ASS patients. In addition, specific glycosylation patterns correlated with lung function parameters. Our study revealed the IgG glycosylation profile in ASS patients and provided a valuable reference for further investigation of its potential diagnostic and prognostic applications. |
| format | Article |
| id | doaj-art-ad112dfb78764f2e86e3d6611d4f715f |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ad112dfb78764f2e86e3d6611d4f715f2025-08-20T03:21:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15382191538219N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome diseaseJing ZhaoYanhong LiYingying LingTong WuYinlan WuChunyu TanLu ChengDeying HuangYi LiuYong ZhangIntroductionAnti-synthetase syndrome (ASS) is a subtype of idiopathic inflammatory myopathy (IIM) characterized by characteristic rash, myositis, and interstitial lung disease (ILD). The etiology of ASS is unknown, and patients have a poor quality of life and are prone to pulmonary infection. Recent studies have elucidated the potential role of abnormal glycosylation of immunoglobulin G (IgG) in the pathogenesis of autoimmune diseases. However, the pattern of patient-specific IgG N-glycosylation in ASS has not been fully elucidated.Methodsthe GlycoQuant method was used to quantify the intact N-glycopeptides of IgG from 30 ASS patients and 30 healthy controls (HCs). Results and DiscussionThirteen differentially expressed intact N-glycopeptides were identified (p<0.05). Notably, we observed increased fucosylation (p<0.0001) and decreased N-acetylneuraminic acid (p<0.05) in ASS patients. In addition, specific glycosylation patterns correlated with lung function parameters. Our study revealed the IgG glycosylation profile in ASS patients and provided a valuable reference for further investigation of its potential diagnostic and prognostic applications.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538219/fullautoimmune diseaseanti-synthetase syndrome (ASS)N-glycosylationintact N-glycopeptideimmunoglobulin g (IgG) |
| spellingShingle | Jing Zhao Yanhong Li Yingying Ling Tong Wu Yinlan Wu Chunyu Tan Lu Cheng Deying Huang Yi Liu Yong Zhang N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease Frontiers in Immunology autoimmune disease anti-synthetase syndrome (ASS) N-glycosylation intact N-glycopeptide immunoglobulin g (IgG) |
| title | N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease |
| title_full | N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease |
| title_fullStr | N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease |
| title_full_unstemmed | N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease |
| title_short | N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease |
| title_sort | n glycosylation patterns of plasma immunoglobulin g in anti synthetase syndrome disease |
| topic | autoimmune disease anti-synthetase syndrome (ASS) N-glycosylation intact N-glycopeptide immunoglobulin g (IgG) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538219/full |
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