Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications
Abstract Alzheimer’s disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to the involvement of lipid dysregulation in the development of AD. Nevertheless, the precise lipidomic landscape and the mechanistic roles of lipids i...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Neurodegeneration |
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| Online Access: | https://doi.org/10.1186/s13024-025-00803-6 |
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| author | Sijia He Ziying Xu Xianlin Han |
| author_facet | Sijia He Ziying Xu Xianlin Han |
| author_sort | Sijia He |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to the involvement of lipid dysregulation in the development of AD. Nevertheless, the precise lipidomic landscape and the mechanistic roles of lipids in disease pathology remain poorly understood. This review aims to highlight the significance of lipidomics and lipid-targeting approaches in the diagnosis and treatment of AD. We summarized the connection between lipid dysregulation in the human brain and AD at both genetic and lipid species levels. We briefly introduced lipidomics technologies and discussed potential challenges and areas of future advancements in the lipidomics field for AD research. To elucidate the central role of lipids in converging multiple pathological aspects of AD, we reviewed the current knowledge on the interplay between lipids and major AD features, including amyloid beta, tau, and neuroinflammation. Finally, we assessed the progresses and obstacles in lipid-based therapeutics and proposed potential strategies for leveraging lipidomics in the treatment of AD. |
| format | Article |
| id | doaj-art-ad104f4a70d848f79f974cfc087b07b4 |
| institution | Kabale University |
| issn | 1750-1326 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj-art-ad104f4a70d848f79f974cfc087b07b42025-02-02T12:42:30ZengBMCMolecular Neurodegeneration1750-13262025-01-0120112710.1186/s13024-025-00803-6Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implicationsSijia He0Ziying Xu1Xianlin Han2Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San AntonioSam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San AntonioSam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San AntonioAbstract Alzheimer’s disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to the involvement of lipid dysregulation in the development of AD. Nevertheless, the precise lipidomic landscape and the mechanistic roles of lipids in disease pathology remain poorly understood. This review aims to highlight the significance of lipidomics and lipid-targeting approaches in the diagnosis and treatment of AD. We summarized the connection between lipid dysregulation in the human brain and AD at both genetic and lipid species levels. We briefly introduced lipidomics technologies and discussed potential challenges and areas of future advancements in the lipidomics field for AD research. To elucidate the central role of lipids in converging multiple pathological aspects of AD, we reviewed the current knowledge on the interplay between lipids and major AD features, including amyloid beta, tau, and neuroinflammation. Finally, we assessed the progresses and obstacles in lipid-based therapeutics and proposed potential strategies for leveraging lipidomics in the treatment of AD.https://doi.org/10.1186/s13024-025-00803-6Alzheimer’s diseaseLipid metabolismLipidomicsLipidome |
| spellingShingle | Sijia He Ziying Xu Xianlin Han Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications Molecular Neurodegeneration Alzheimer’s disease Lipid metabolism Lipidomics Lipidome |
| title | Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications |
| title_full | Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications |
| title_fullStr | Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications |
| title_full_unstemmed | Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications |
| title_short | Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications |
| title_sort | lipidome disruption in alzheimer s disease brain detection pathological mechanisms and therapeutic implications |
| topic | Alzheimer’s disease Lipid metabolism Lipidomics Lipidome |
| url | https://doi.org/10.1186/s13024-025-00803-6 |
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