Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction
ABSTRACT Acute pancreatitis is inflammation of the pancreas and is most commonly caused by gallstones, alcohol use, hyperlipidemia, or idiopathic. Drug‐induced acute pancreatitis is relatively rare and often under‐recognized; it accounts for 0.1%–2% of all cases. Among many drugs, thiazide diuretics...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70813 |
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| author | Kshitiz Pandey Ashish Panday Pratik Pandey Anand Chaudhary Sushmita Khanal |
| author_facet | Kshitiz Pandey Ashish Panday Pratik Pandey Anand Chaudhary Sushmita Khanal |
| author_sort | Kshitiz Pandey |
| collection | DOAJ |
| description | ABSTRACT Acute pancreatitis is inflammation of the pancreas and is most commonly caused by gallstones, alcohol use, hyperlipidemia, or idiopathic. Drug‐induced acute pancreatitis is relatively rare and often under‐recognized; it accounts for 0.1%–2% of all cases. Among many drugs, thiazide diuretics are infrequently implicated but remain a known cause. We report a case of a 55‐year‐old male who presented with acute epigastric pain, nausea, and vomiting 2 weeks after adding thiazide for persistent secondary hypertension. Laboratory investigations revealed elevated pancreatic enzyme levels, and contrast‐enhanced computed tomography confirmed acute interstitial pancreatitis. Comprehensive evaluation excluded common etiologies including gallstones (ultrasound, CT‐scan, and MRCP), alcohol use (history), and dyslipidemia (normal lipid profile). The temporal relationship between drug initiation and symptom onset made thiazide‐induced pancreatitis a likely diagnosis. Discontinuation of hydrochlorothiazide led to clinical improvement for the patient. This case highlights the importance of considering thiazide‐induced pancreatitis in patients who present with acute pancreatitis when the common risk factors are absent. While extensive investigation to search for other rare causes of acute pancreatitis should be done, prompt recognition and withdrawal of the possible offending agent are essential for patient recovery and prevention of recurrence. |
| format | Article |
| id | doaj-art-ad0d689ce8ae435085f8570a3e0d1434 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-ad0d689ce8ae435085f8570a3e0d14342025-08-22T07:33:08ZengWileyClinical Case Reports2050-09042025-08-01138n/an/a10.1002/ccr3.70813Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug ReactionKshitiz Pandey0Ashish Panday1Pratik Pandey2Anand Chaudhary3Sushmita Khanal4Bakulahar Ratnanagar Hopsital Chitwan NepalBakulahar Ratnanagar Hopsital Chitwan NepalBakulahar Ratnanagar Hopsital Chitwan NepalTribhuvan University Teaching Hospital Kathmandu NepalNobel Medical College Teaching Hospital Biratnagar NepalABSTRACT Acute pancreatitis is inflammation of the pancreas and is most commonly caused by gallstones, alcohol use, hyperlipidemia, or idiopathic. Drug‐induced acute pancreatitis is relatively rare and often under‐recognized; it accounts for 0.1%–2% of all cases. Among many drugs, thiazide diuretics are infrequently implicated but remain a known cause. We report a case of a 55‐year‐old male who presented with acute epigastric pain, nausea, and vomiting 2 weeks after adding thiazide for persistent secondary hypertension. Laboratory investigations revealed elevated pancreatic enzyme levels, and contrast‐enhanced computed tomography confirmed acute interstitial pancreatitis. Comprehensive evaluation excluded common etiologies including gallstones (ultrasound, CT‐scan, and MRCP), alcohol use (history), and dyslipidemia (normal lipid profile). The temporal relationship between drug initiation and symptom onset made thiazide‐induced pancreatitis a likely diagnosis. Discontinuation of hydrochlorothiazide led to clinical improvement for the patient. This case highlights the importance of considering thiazide‐induced pancreatitis in patients who present with acute pancreatitis when the common risk factors are absent. While extensive investigation to search for other rare causes of acute pancreatitis should be done, prompt recognition and withdrawal of the possible offending agent are essential for patient recovery and prevention of recurrence.https://doi.org/10.1002/ccr3.70813acute pancreatitisdrug‐induced pancreatitishypertensioninterstitial pancreatitisthiazide diuretics |
| spellingShingle | Kshitiz Pandey Ashish Panday Pratik Pandey Anand Chaudhary Sushmita Khanal Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction Clinical Case Reports acute pancreatitis drug‐induced pancreatitis hypertension interstitial pancreatitis thiazide diuretics |
| title | Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction |
| title_full | Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction |
| title_fullStr | Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction |
| title_full_unstemmed | Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction |
| title_short | Thiazide‐Induced Acute Interstitial Pancreatitis in a 55‐Year‐Old Male: A Rare Adverse Drug Reaction |
| title_sort | thiazide induced acute interstitial pancreatitis in a 55 year old male a rare adverse drug reaction |
| topic | acute pancreatitis drug‐induced pancreatitis hypertension interstitial pancreatitis thiazide diuretics |
| url | https://doi.org/10.1002/ccr3.70813 |
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