PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine

PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine

ABSTRACT Leukopenia is a common dose‐dependent side effect of azathioprine, often leading to drug discontinuation. Variants in TPMT and NUDT15 are associated with azathioprine‐induced leukopenia but only explain 25% of cases. Thus, we aimed to identify novel genetic risk factors among TPMT and NUDT1...

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Main Authors: Laura L. Daniel, Puran Nepal, Jacy Zanussi, Alyson L. Dickson, Peter Straub, Tyne W. Miller‐Fleming, Wei‐Qi Wei, Adriana M. Hung, Nancy J. Cox, Vivian K. Kawai, Jonathan D. Mosley, Charles Michael Stein, QiPing Feng, Ge Liu, Ran Tao, Cecilia P. Chung
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Clinical and Translational Science
Subjects:
azathioprine
GWAS
leukopenia
personalized medicine
pharmacogenetics
pharmacogenomics
Online Access:https://doi.org/10.1111/cts.70220
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