Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New
Pathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified. However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well established. Among T cells, IL-17 producing T helpe...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/823085 |
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| author | Alessia Alunno Elena Bartoloni Onelia Bistoni Giuseppe Nocentini Simona Ronchetti Sara Caterbi Valentina Valentini Carlo Riccardi Roberto Gerli |
| author_facet | Alessia Alunno Elena Bartoloni Onelia Bistoni Giuseppe Nocentini Simona Ronchetti Sara Caterbi Valentina Valentini Carlo Riccardi Roberto Gerli |
| author_sort | Alessia Alunno |
| collection | DOAJ |
| description | Pathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified. However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well established. Among T cells, IL-17 producing T helper (Th17) cells and regulatory T (Treg) cells represent an intriguing issue to be addressed in SLE pathogenesis, since an imbalance between the two subsets has been observed in the course of the disease. Treg cells appear to be impaired and therefore unable to counteract autoreactive T lymphocytes. Conversely, Th17 cells accumulate in target organs contributing to local IL-17 production and eventually tissue damage. In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent an intriguing and useful tool for SLE treatment in the next future. In this paper, the current knowledge about Treg and Th17 cells interplay in SLE will be discussed. |
| format | Article |
| id | doaj-art-ad072ca6a7f24bb6bb9502ffe890afc7 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-ad072ca6a7f24bb6bb9502ffe890afc72025-02-03T05:57:45ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/823085823085Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the NewAlessia Alunno0Elena Bartoloni1Onelia Bistoni2Giuseppe Nocentini3Simona Ronchetti4Sara Caterbi5Valentina Valentini6Carlo Riccardi7Roberto Gerli8Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalySection of Pharmacology, Toxicology and Chemotherapy, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalySection of Pharmacology, Toxicology and Chemotherapy, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalySection of Pharmacology, Toxicology and Chemotherapy, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Via Enrico dal Pozzo, 06122 Perugia, ItalyPathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified. However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well established. Among T cells, IL-17 producing T helper (Th17) cells and regulatory T (Treg) cells represent an intriguing issue to be addressed in SLE pathogenesis, since an imbalance between the two subsets has been observed in the course of the disease. Treg cells appear to be impaired and therefore unable to counteract autoreactive T lymphocytes. Conversely, Th17 cells accumulate in target organs contributing to local IL-17 production and eventually tissue damage. In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent an intriguing and useful tool for SLE treatment in the next future. In this paper, the current knowledge about Treg and Th17 cells interplay in SLE will be discussed.http://dx.doi.org/10.1155/2012/823085 |
| spellingShingle | Alessia Alunno Elena Bartoloni Onelia Bistoni Giuseppe Nocentini Simona Ronchetti Sara Caterbi Valentina Valentini Carlo Riccardi Roberto Gerli Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New Clinical and Developmental Immunology |
| title | Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New |
| title_full | Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New |
| title_fullStr | Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New |
| title_full_unstemmed | Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New |
| title_short | Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New |
| title_sort | balance between regulatory t and th17 cells in systemic lupus erythematosus the old and the new |
| url | http://dx.doi.org/10.1155/2012/823085 |
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