Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS)
Aims. To compare metabolic profiles and the long-term risk of metabolic dysfunction between women with previous gestational diabetes mellitus (pGDM) and women without pGDM (non-GDM) matched on age, prepregnancy body mass index (BMI), and parity. Methods. In total, 128 women with pGDM (median follow-...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/4900209 |
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| author | Kristine Hovde Jacobsen Jori Aalders Katrine Sølling Marianne Skovsager Andersen Lena Sønder Snogdal Maria Hornstrup Christensen Christina Anne Vinter Kurt Højlund Dorte Møller Jensen |
| author_facet | Kristine Hovde Jacobsen Jori Aalders Katrine Sølling Marianne Skovsager Andersen Lena Sønder Snogdal Maria Hornstrup Christensen Christina Anne Vinter Kurt Højlund Dorte Møller Jensen |
| author_sort | Kristine Hovde Jacobsen |
| collection | DOAJ |
| description | Aims. To compare metabolic profiles and the long-term risk of metabolic dysfunction between women with previous gestational diabetes mellitus (pGDM) and women without pGDM (non-GDM) matched on age, prepregnancy body mass index (BMI), and parity. Methods. In total, 128 women with pGDM (median follow-up: 7.8 years) and 70 non-GDM controls (median follow-up: 10.0 years) completed a 2 h oral glucose tolerance test (OGTT) with assessment of glucose, C-peptide, insulin, and other metabolic measures. Additionally, anthropometrics, fat mass, and blood pressure were assessed and indices of insulin sensitivity and beta cell function were calculated. Results. The prevalence of type 2 diabetes mellitus (T2DM) was significantly higher in the pGDM group compared to the non-GDM group (26% vs. 0%). For women with pGDM, the prevalence of prediabetes (38%) and the metabolic syndrome (MetS) (59%) were approximately 3-fold higher than in non-GDM women (p’s<0.001). Both insulin sensitivity and beta cell function were significantly reduced in pGDM women compared to non-GDM women. Conclusion. Despite similar BMI, women with pGDM had a substantially higher risk of developing T2DM, prediabetes, and the MetS compared to controls. Both beta cell dysfunction and reduced insulin sensitivity seem to contribute to this increased risk. |
| format | Article |
| id | doaj-art-ad059e1ed5934b159198d778c1fce42b |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ad059e1ed5934b159198d778c1fce42b2025-02-03T01:32:34ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/4900209Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS)Kristine Hovde Jacobsen0Jori Aalders1Katrine Sølling2Marianne Skovsager Andersen3Lena Sønder Snogdal4Maria Hornstrup Christensen5Christina Anne Vinter6Kurt Højlund7Dorte Møller Jensen8Steno Diabetes Center OdenseSteno Diabetes Center OdenseSteno Diabetes Center OdenseDepartment of Clinical ResearchSteno Diabetes Center OdenseSteno Diabetes Center OdenseSteno Diabetes Center OdenseSteno Diabetes Center OdenseSteno Diabetes Center OdenseAims. To compare metabolic profiles and the long-term risk of metabolic dysfunction between women with previous gestational diabetes mellitus (pGDM) and women without pGDM (non-GDM) matched on age, prepregnancy body mass index (BMI), and parity. Methods. In total, 128 women with pGDM (median follow-up: 7.8 years) and 70 non-GDM controls (median follow-up: 10.0 years) completed a 2 h oral glucose tolerance test (OGTT) with assessment of glucose, C-peptide, insulin, and other metabolic measures. Additionally, anthropometrics, fat mass, and blood pressure were assessed and indices of insulin sensitivity and beta cell function were calculated. Results. The prevalence of type 2 diabetes mellitus (T2DM) was significantly higher in the pGDM group compared to the non-GDM group (26% vs. 0%). For women with pGDM, the prevalence of prediabetes (38%) and the metabolic syndrome (MetS) (59%) were approximately 3-fold higher than in non-GDM women (p’s<0.001). Both insulin sensitivity and beta cell function were significantly reduced in pGDM women compared to non-GDM women. Conclusion. Despite similar BMI, women with pGDM had a substantially higher risk of developing T2DM, prediabetes, and the MetS compared to controls. Both beta cell dysfunction and reduced insulin sensitivity seem to contribute to this increased risk.http://dx.doi.org/10.1155/2022/4900209 |
| spellingShingle | Kristine Hovde Jacobsen Jori Aalders Katrine Sølling Marianne Skovsager Andersen Lena Sønder Snogdal Maria Hornstrup Christensen Christina Anne Vinter Kurt Højlund Dorte Møller Jensen Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS) Journal of Diabetes Research |
| title | Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS) |
| title_full | Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS) |
| title_fullStr | Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS) |
| title_full_unstemmed | Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS) |
| title_short | Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results from the Odense GDM Follow-Up Study (OGFUS) |
| title_sort | long term metabolic outcomes after gestational diabetes mellitus gdm results from the odense gdm follow up study ogfus |
| url | http://dx.doi.org/10.1155/2022/4900209 |
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