Mouse MRE11-RAD50-NBS1 is needed to start and extend meiotic DNA end resection

Mouse MRE11-RAD50-NBS1 is needed to start and extend meiotic DNA end resection

Abstract Nucleolytic resection of DNA ends is critical for homologous recombination, but its mechanism is not fully understood, particularly in mammalian meiosis. Here we examine roles of the conserved MRN complex (MRE11, RAD50, and NBS1) through genome-wide analysis of meiotic resection during sper...

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Main Authors: Soonjoung Kim, Shintaro Yamada, Tao Li, Claudia Canasto-Chibuque, Jun Hyun Kim, Marina Marcet-Ortega, Jiaqi Xu, Diana Y. Eng, Laura Feeney, John H. J. Petrini, Scott Keeney
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57928-x
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