Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in a variety of cell types and are involved in multiple physiological regulatory mechanisms in cells, tissues and systems. Increasing evidence suggests that the α5 nicotinic acetylcholine receptor (α5-nAChR), encoded by the CHRNA5 gene,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1489958/full |
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| _version_ | 1850228630331850752 |
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| author | Jiaying Cai Jingting Wang Zengping Wang Jing Wang Yanfei Jia Xiaoli Ma |
| author_facet | Jiaying Cai Jingting Wang Zengping Wang Jing Wang Yanfei Jia Xiaoli Ma |
| author_sort | Jiaying Cai |
| collection | DOAJ |
| description | Nicotinic acetylcholine receptors (nAChRs) are widely expressed in a variety of cell types and are involved in multiple physiological regulatory mechanisms in cells, tissues and systems. Increasing evidence suggests that the α5 nicotinic acetylcholine receptor (α5-nAChR), encoded by the CHRNA5 gene, is one of a key mediator involved in lung cancer development and immune responses. Several studies have shown that it is a regulator that stimulates processes via various signaling pathways, including STAT3 in lung cancer. In addition, α5-nAChR has a profound effect on lung immune response through multiple immune-related factor pathways. In this review, we focus on the perspectives on α5-nAChR in lung cancer progression, which indicates that targeting α5-nAChR could provide novel anticancer and immune therapy strategies for lung cancer. |
| format | Article |
| id | doaj-art-ad00a2d46f134264b5e227201006ad71 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-ad00a2d46f134264b5e227201006ad712025-08-20T02:04:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.14899581489958Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progressionJiaying CaiJingting WangZengping WangJing WangYanfei JiaXiaoli MaNicotinic acetylcholine receptors (nAChRs) are widely expressed in a variety of cell types and are involved in multiple physiological regulatory mechanisms in cells, tissues and systems. Increasing evidence suggests that the α5 nicotinic acetylcholine receptor (α5-nAChR), encoded by the CHRNA5 gene, is one of a key mediator involved in lung cancer development and immune responses. Several studies have shown that it is a regulator that stimulates processes via various signaling pathways, including STAT3 in lung cancer. In addition, α5-nAChR has a profound effect on lung immune response through multiple immune-related factor pathways. In this review, we focus on the perspectives on α5-nAChR in lung cancer progression, which indicates that targeting α5-nAChR could provide novel anticancer and immune therapy strategies for lung cancer.https://www.frontiersin.org/articles/10.3389/fcell.2025.1489958/fullα5-nAChRgrowthepithelial-mesenchymal transition (EMT)immune escapelung cancer |
| spellingShingle | Jiaying Cai Jingting Wang Zengping Wang Jing Wang Yanfei Jia Xiaoli Ma Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression Frontiers in Cell and Developmental Biology α5-nAChR growth epithelial-mesenchymal transition (EMT) immune escape lung cancer |
| title | Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression |
| title_full | Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression |
| title_fullStr | Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression |
| title_full_unstemmed | Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression |
| title_short | Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression |
| title_sort | perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression |
| topic | α5-nAChR growth epithelial-mesenchymal transition (EMT) immune escape lung cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1489958/full |
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