Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease
Bei Ye,1 Jiying Xiao,2 Caiyun Zhang3 1Department of Pediatrics, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Respiratory Medicine, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Pediatric Intensive Care Uni...
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Dove Medical Press
2024-12-01
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| author | Ye B Xiao J Zhang C |
| author_facet | Ye B Xiao J Zhang C |
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| description | Bei Ye,1 Jiying Xiao,2 Caiyun Zhang3 1Department of Pediatrics, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Respiratory Medicine, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Pediatric Intensive Care Unit, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Caiyun Zhang, Department of Pediatric Intensive Care Unit, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China, Email zcyzwj@163.comObjective: To investigate the predictive value of T-lymphocyte activation-related cytokines in non-responsive Kawasaki disease.Methods: Eighty-two children with Kawasaki disease, hospitalized from June 2022 to December 2023, were divided into two groups based on treatment response: the sensitive Kawasaki disease group (n=71) and the non-responsive Kawasaki disease group (n=11). Serum levels of T-lymph activation-related cytokines, including interleukin-2, 6, 7, 12, 15, 17, and tumor necrosis factor alpha, were measured before and after IVIG treatment in both groups. The differences in cytokine levels between the two groups were compared pre- and post-treatment. The ability of these cytokines to discriminate non-responsive Kawasaki disease was evaluated using ROC curves to determine the cut-off value.Results: Before initial treatment, IL-2, IL-6, IL-7, IL-12, IL-15, IL-17, and tumor necrosis factor-α values were significantly higher in the non-responsive Kawasaki disease group compared to the sensitive Kawasaki disease group. Comparisons before and after initial treatment showed significant decreases in IL-6 and 17 in the sensitive Kawasaki disease group and significant decreases in IL-6 and 7 in the non-responsive Kawasaki disease group. IL-6 and 17 significantly increased in the sensitive group compared to the non-responsive group after initial treatment. The ROC curves indicated that IL-6 predicted the area under the curve (AUC) for non-responsive Kawasaki disease to be 0.859 before treatment and 0.920 after treatment. Similarly, IL-17 had AUC values of 0.699 before treatment and 0.884 after treatment.Conclusion: Reassessing IL-6 and IL-17 following the initial treatment for Kawasaki disease may improve early warning signals for unresponsive Kawasaki disease.Keywords: Kawasaki disease, unresponsive Kawasaki disease, cytokines, T-lymphocyte activation, immunoglobulin |
| format | Article |
| id | doaj-art-acf7bfeb9b0947a5b6085fbcab220f50 |
| institution | OA Journals |
| issn | 1179-9927 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dove Medical Press |
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| series | Pediatric Health, Medicine and Therapeutics |
| spelling | doaj-art-acf7bfeb9b0947a5b6085fbcab220f502025-08-20T01:58:22ZengDove Medical PressPediatric Health, Medicine and Therapeutics1179-99272024-12-01Volume 1537538398404Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki DiseaseYe BXiao JZhang CBei Ye,1 Jiying Xiao,2 Caiyun Zhang3 1Department of Pediatrics, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Respiratory Medicine, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Pediatric Intensive Care Unit, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Caiyun Zhang, Department of Pediatric Intensive Care Unit, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China, Email zcyzwj@163.comObjective: To investigate the predictive value of T-lymphocyte activation-related cytokines in non-responsive Kawasaki disease.Methods: Eighty-two children with Kawasaki disease, hospitalized from June 2022 to December 2023, were divided into two groups based on treatment response: the sensitive Kawasaki disease group (n=71) and the non-responsive Kawasaki disease group (n=11). Serum levels of T-lymph activation-related cytokines, including interleukin-2, 6, 7, 12, 15, 17, and tumor necrosis factor alpha, were measured before and after IVIG treatment in both groups. The differences in cytokine levels between the two groups were compared pre- and post-treatment. The ability of these cytokines to discriminate non-responsive Kawasaki disease was evaluated using ROC curves to determine the cut-off value.Results: Before initial treatment, IL-2, IL-6, IL-7, IL-12, IL-15, IL-17, and tumor necrosis factor-α values were significantly higher in the non-responsive Kawasaki disease group compared to the sensitive Kawasaki disease group. Comparisons before and after initial treatment showed significant decreases in IL-6 and 17 in the sensitive Kawasaki disease group and significant decreases in IL-6 and 7 in the non-responsive Kawasaki disease group. IL-6 and 17 significantly increased in the sensitive group compared to the non-responsive group after initial treatment. The ROC curves indicated that IL-6 predicted the area under the curve (AUC) for non-responsive Kawasaki disease to be 0.859 before treatment and 0.920 after treatment. Similarly, IL-17 had AUC values of 0.699 before treatment and 0.884 after treatment.Conclusion: Reassessing IL-6 and IL-17 following the initial treatment for Kawasaki disease may improve early warning signals for unresponsive Kawasaki disease.Keywords: Kawasaki disease, unresponsive Kawasaki disease, cytokines, T-lymphocyte activation, immunoglobulinhttps://www.dovepress.com/utilizing-t-lymphocyte-activation-related-cytokines-to-predict-non-res-peer-reviewed-fulltext-article-PHMTkawasaki disease;unresponsive kawasaki disease;cytokines;t-lymphocyte activation;immunoglobulin |
| spellingShingle | Ye B Xiao J Zhang C Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease Pediatric Health, Medicine and Therapeutics kawasaki disease;unresponsive kawasaki disease;cytokines;t-lymphocyte activation;immunoglobulin |
| title | Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease |
| title_full | Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease |
| title_fullStr | Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease |
| title_full_unstemmed | Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease |
| title_short | Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease |
| title_sort | utilizing t lymphocyte activation related cytokines to predict non responsiveness to treatment in pediatric kawasaki disease |
| topic | kawasaki disease;unresponsive kawasaki disease;cytokines;t-lymphocyte activation;immunoglobulin |
| url | https://www.dovepress.com/utilizing-t-lymphocyte-activation-related-cytokines-to-predict-non-res-peer-reviewed-fulltext-article-PHMT |
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