Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma

Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma

Abstract Head and neck squamous cell carcinoma (HNSCC) remains among the most aggressive malignancies with limited treatment options, especially in recurrent and metastatic cases. Despite advances in surgery, radiotherapy, chemotherapy, and immune checkpoint inhibitors, survival rates remain subopti...

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Main Authors: Sahand Saeidpour Masouleh, Kamyar Nasiri, Ava Ostovar Ravari, Mona Saligheh Rad, Kiarash kiani, Ali Sharifi Sultani, Seyedeh Tabasom Nejati, Mohsen Nabi Afjadi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Biomarker Research
Subjects:
Head and neck squamous cell carcinoma
Chimeric antigen receptor T-cell therapy
Immunotherapy
CRISPR
Online Access:https://doi.org/10.1186/s40364-025-00783-1
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