Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative Stress
The term diabetes mellitus defines metabolic alterations of multiple etiologies characterized by chronic hyperglycemia and disorders in the metabolism of carbohydrates, fats, and proteins, resulting from defects in insulin secretion, insulin action, or both. When insulin binds to its receptor, it tr...
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Universidad de las Ciencias Médicas de Cienfuegos
2020-09-01
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| Series: | Revista Finlay |
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| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/764 |
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| author | Dayamí García Torres María de Jesús Sánchez Bouza Pedro Javier Sánchez Sánchez Pedro Sánchez Frenes Laura Naranjo Hernández |
| author_facet | Dayamí García Torres María de Jesús Sánchez Bouza Pedro Javier Sánchez Sánchez Pedro Sánchez Frenes Laura Naranjo Hernández |
| author_sort | Dayamí García Torres |
| collection | DOAJ |
| description | The term diabetes mellitus defines metabolic alterations of multiple etiologies characterized by chronic hyperglycemia and disorders in the metabolism of carbohydrates, fats, and proteins, resulting from defects in insulin secretion, insulin action, or both. When insulin binds to its receptor, it triggers multiple molecular signaling pathways, which mediate its biological actions. Alterations in the receptor or downstream effect or molecules cause increased levels of glucose in the blood. Non-enzymatic glycosylation phenomena occur spontaneously in the human body, favoring the formation of free radicals. This review presents an update on the relationship between the molecular bases of insulin actions and the mechanisms involved in regulating its effects with non-enzymatic glycosylation processes and concomitant oxidative stress. The study of these interrelationships and their metabolic links will allow a better understanding of the causes associated with the complications of this entity. |
| format | Article |
| id | doaj-art-acf22e2f0b1e4179b926fba592a20467 |
| institution | Kabale University |
| issn | 2221-2434 |
| language | Spanish |
| publishDate | 2020-09-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj-art-acf22e2f0b1e4179b926fba592a204672025-01-30T21:22:00ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342020-09-01103293303457Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative StressDayamí García Torres0María de Jesús Sánchez Bouza1Pedro Javier Sánchez Sánchez2Pedro Sánchez Frenes3Laura Naranjo Hernández4Hospital General Universitario Dr. Gustavo Aldereguía Lima. Cienfuegos.Universidad de Ciencias Médicas de Cienfuegos. Cienfuegos.Hospital General Universitario Dr. Gustavo Aldereguía Lima. Cienfuegos.Banco de Sangre Provincial. Cienfuegos.Universidad de Ciencias Médicas de Cienfuegos. Cienfuegos.The term diabetes mellitus defines metabolic alterations of multiple etiologies characterized by chronic hyperglycemia and disorders in the metabolism of carbohydrates, fats, and proteins, resulting from defects in insulin secretion, insulin action, or both. When insulin binds to its receptor, it triggers multiple molecular signaling pathways, which mediate its biological actions. Alterations in the receptor or downstream effect or molecules cause increased levels of glucose in the blood. Non-enzymatic glycosylation phenomena occur spontaneously in the human body, favoring the formation of free radicals. This review presents an update on the relationship between the molecular bases of insulin actions and the mechanisms involved in regulating its effects with non-enzymatic glycosylation processes and concomitant oxidative stress. The study of these interrelationships and their metabolic links will allow a better understanding of the causes associated with the complications of this entity.https://revfinlay.sld.cu/index.php/finlay/article/view/764diabetes mellitustrastornos metabólicosinsulinaestrés oxidativo |
| spellingShingle | Dayamí García Torres María de Jesús Sánchez Bouza Pedro Javier Sánchez Sánchez Pedro Sánchez Frenes Laura Naranjo Hernández Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative Stress Revista Finlay diabetes mellitus trastornos metabólicos insulina estrés oxidativo |
| title | Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative Stress |
| title_full | Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative Stress |
| title_fullStr | Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative Stress |
| title_full_unstemmed | Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative Stress |
| title_short | Molecular Bases of Diabetes Mellitus and its Relationship with non-enzymatic Glycosylation and Oxidative Stress |
| title_sort | molecular bases of diabetes mellitus and its relationship with non enzymatic glycosylation and oxidative stress |
| topic | diabetes mellitus trastornos metabólicos insulina estrés oxidativo |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/764 |
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