Ganoderic acid a potentiates cisplatin’s cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness

Ganoderic acid a potentiates cisplatin’s cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness

Abstract Background Ganoderma acid A (GAA), a triterpenoid compound from Ganoderma lucidum, has gained attention for its anti-tumor properties. Herein, we hypothesized that GAA may enhance cisplatin’s (DDP) anticancer effect in gallbladder cancer (GBC) cells by promoting DNA damage response, particu...

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Bibliographic Details
Main Authors: Gan Zhang, Haoming Lan, Jie Wu, Xianfeng Sheng, Linsheng Huang, Meng Zhou, Jun Hu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:World Journal of Surgical Oncology
Subjects:
Ganoderic acid A
Cisplatin
Gallbladder cancer
DNA damage response
Cell stemness
Apoptosis
Online Access:https://doi.org/10.1186/s12957-025-03799-x
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