KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY
Objective: Our study was performed on 49 chronic lymphocytic leukemia (CLL) patients followed in the outpatient clinic of the Istanbul University Cerrahpasa Medical Faculty Department of Hematology. We aimed to analyze the relationship between autoimmune phenomena and CLL. Methods: Twenty-five CLL p...
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Istanbul University Press
2021-04-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/38EA946EA87840C7AA86E0FA244C8192 |
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| author | Mustafa Murat Özbalak Işıl Erdoğan Özünal Selin Berk Tuğrul Elverdi Ayşe Salihoğlu Ahmet Emre Eşkazan Ezgi Pınar Özbalak Muhlis Cem Ar Şeniz Öngören Zafer Başlar Yıldız Aydın Seda Ekizoğlu Asuman Çelebi Ayşe Nur Buyru Teoman Soysal |
| author_facet | Mustafa Murat Özbalak Işıl Erdoğan Özünal Selin Berk Tuğrul Elverdi Ayşe Salihoğlu Ahmet Emre Eşkazan Ezgi Pınar Özbalak Muhlis Cem Ar Şeniz Öngören Zafer Başlar Yıldız Aydın Seda Ekizoğlu Asuman Çelebi Ayşe Nur Buyru Teoman Soysal |
| author_sort | Mustafa Murat Özbalak |
| collection | DOAJ |
| description | Objective: Our study was performed on 49 chronic lymphocytic leukemia (CLL) patients followed in the outpatient clinic of the Istanbul University Cerrahpasa Medical Faculty Department of Hematology. We aimed to analyze the relationship between autoimmune phenomena and CLL. Methods: Twenty-five CLL patients with and 24 CLL patients without autoimmune phenomenon were included. Thirty-two of them were male and 17 were female. No statistically significant difference in the median age at diagnosis (60 vs 64) and in the median follow-up time (59 months vs 71 months) was detected. The initial diagnostic parameters were similar. Results: In our autoimmune phenomenon cohort, the most frequent autoimmune disease was autoimmune hemolytic anemia (AIHA) followed by immune thrombocytopenia (ITP) and pure red cell aplasia (PRCA). The direct antiglobulin positivity at the time of diagnosis was increased in the autoimmune phenomenon group (p=0.024). Additionally, the stage of CLL in patients ofthe autoimmune phenomenon group was more advanced than the other group (p=0.04). Although the number of autoimmune phenomena was not high enough, the CD38 positive cell ratio over 30% in the peripheral blood was more frequent in PRCA group (p=0.008). Conclusion: We could not determine a relationship between autoimmunity in CLL and KIR genotypes. We believe that a new study in a larger cohort with superior technical conditions should be planned to find accurate responses to our study. |
| format | Article |
| id | doaj-art-acebda739933453a9daf07c080c243c8 |
| institution | OA Journals |
| issn | 1305-6441 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-acebda739933453a9daf07c080c243c82025-08-20T01:50:22ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412021-04-0184222723610.26650/IUITFD.2020.0037123456KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITYMustafa Murat Özbalak0https://orcid.org/0000-0002-3040-4052Işıl Erdoğan Özünal1https://orcid.org/0000-0002-5289-7134Selin Berk2https://orcid.org/0000-0001-7495-0218Tuğrul Elverdi3https://orcid.org/0000-0001-9496-5353Ayşe Salihoğlu4https://orcid.org/0000-0002-8758-7945Ahmet Emre Eşkazan5https://orcid.org/0000-0001-9568-0894Ezgi Pınar Özbalak6https://orcid.org/0000-0003-1722-8602Muhlis Cem Ar7https://orcid.org/0000-0002-0332-9253Şeniz Öngören8https://orcid.org/0000-0002-2809-5510Zafer Başlar9https://orcid.org/0000-0002-1807-7351Yıldız Aydın10https://orcid.org/0000-0002-1615-5256Seda Ekizoğlu11https://orcid.org/0000-0003-4785-8189Asuman Çelebi12https://orcid.org/0000-0003-0960-6351Ayşe Nur Buyru13https://orcid.org/0000-0002-6920-1455Teoman Soysal14https://orcid.org/0000-0002-7417-2118İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Medeniyet Üniversitesi, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, TurkiyeObjective: Our study was performed on 49 chronic lymphocytic leukemia (CLL) patients followed in the outpatient clinic of the Istanbul University Cerrahpasa Medical Faculty Department of Hematology. We aimed to analyze the relationship between autoimmune phenomena and CLL. Methods: Twenty-five CLL patients with and 24 CLL patients without autoimmune phenomenon were included. Thirty-two of them were male and 17 were female. No statistically significant difference in the median age at diagnosis (60 vs 64) and in the median follow-up time (59 months vs 71 months) was detected. The initial diagnostic parameters were similar. Results: In our autoimmune phenomenon cohort, the most frequent autoimmune disease was autoimmune hemolytic anemia (AIHA) followed by immune thrombocytopenia (ITP) and pure red cell aplasia (PRCA). The direct antiglobulin positivity at the time of diagnosis was increased in the autoimmune phenomenon group (p=0.024). Additionally, the stage of CLL in patients ofthe autoimmune phenomenon group was more advanced than the other group (p=0.04). Although the number of autoimmune phenomena was not high enough, the CD38 positive cell ratio over 30% in the peripheral blood was more frequent in PRCA group (p=0.008). Conclusion: We could not determine a relationship between autoimmunity in CLL and KIR genotypes. We believe that a new study in a larger cohort with superior technical conditions should be planned to find accurate responses to our study.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/38EA946EA87840C7AA86E0FA244C8192chronic lymphocytic leukemiakiller immunoglobuline like receptorautoimmunityautoimmune hemolytic anemiaimmune thrombocytopenic purpurapure erythroid aplasia |
| spellingShingle | Mustafa Murat Özbalak Işıl Erdoğan Özünal Selin Berk Tuğrul Elverdi Ayşe Salihoğlu Ahmet Emre Eşkazan Ezgi Pınar Özbalak Muhlis Cem Ar Şeniz Öngören Zafer Başlar Yıldız Aydın Seda Ekizoğlu Asuman Çelebi Ayşe Nur Buyru Teoman Soysal KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY İstanbul Tıp Fakültesi Dergisi chronic lymphocytic leukemia killer immunoglobuline like receptor autoimmunity autoimmune hemolytic anemia immune thrombocytopenic purpura pure erythroid aplasia |
| title | KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY |
| title_full | KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY |
| title_fullStr | KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY |
| title_full_unstemmed | KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY |
| title_short | KILLER IMMUNOGLOBULINE LIKE RECEPTOR GENE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA AND ITS RELATION WITH AUTOIMMUNITY |
| title_sort | killer immunoglobuline like receptor gene analysis in chronic lymphocytic leukemia and its relation with autoimmunity |
| topic | chronic lymphocytic leukemia killer immunoglobuline like receptor autoimmunity autoimmune hemolytic anemia immune thrombocytopenic purpura pure erythroid aplasia |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/38EA946EA87840C7AA86E0FA244C8192 |
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