Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners.

Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners.

We studied patterns of off-target receptor interactions, mostly at G protein-coupled receptors (GPCRs) in the µM range, of nucleoside derivatives that are highly engineered for nM interaction with adenosine receptors (ARs). Because of the considerable interest of using AR ligands for treating diseas...

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Bibliographic Details
Main Authors: Silvia Paoletta, Dilip K Tosh, Daniela Salvemini, Kenneth A Jacobson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0097858
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