Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis
Introduction: A pharmacoeconomic analysis model was developed to evaluate the cost-effectiveness of antibiotics from a societal perspective in Korea and China. A network meta-analysis was conducted to evaluate the efficacy of antibiotics. Methodology: We conducted a systematic search for randomiz...
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The Journal of Infection in Developing Countries
2025-01-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/19228 |
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| author | Chaoxin Chen Tingting Chen Dan Xue Maobai Liu Bin Zheng |
| author_facet | Chaoxin Chen Tingting Chen Dan Xue Maobai Liu Bin Zheng |
| author_sort | Chaoxin Chen |
| collection | DOAJ |
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Introduction: A pharmacoeconomic analysis model was developed to evaluate the cost-effectiveness of antibiotics from a societal perspective in Korea and China. A network meta-analysis was conducted to evaluate the efficacy of antibiotics.
Methodology: We conducted a systematic search for randomized controlled trials or quasi-randomized controlled trials on antibiotics employed as therapy in scrub typhus management. We performed a network meta-analysis to obtain their relative efficacy. The outcome measures for efficacy were cure rate and non-relapse rate. To evaluate their relative cost-effectiveness in Korea and China, a decision analytic model simulating a cohort of scrub typhus patients using antibiotics as therapy was constructed from a societal perspective over 8 weeks. The number of cure cases per 1000 patients and the incremental cost-effectiveness ratio (ICER) was calculated.
Results: We identified 11 relevant articles for network meta-analysis. Of the seven comparisons (azithromycin, chloramphenicol, doxycycline, high-dose rifampin, low-dose rifampin, telithromycin, tetracycline) included in the network meta-analysis, tetracycline was the most effective drug for the treatment of scrub typhus, but the difference is not significant. In the cost-effectiveness analysis, all the treatments were dominated by tetracycline in Korea and China.
Conclusions: Tetracycline is the most economic drug for the treatment of scrub typhus. Hence, tetracycline is recommended as the first choice for the treatment of scrub typhus without contraindications in China and Korea.
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| format | Article |
| id | doaj-art-ace72eb82a04499ab63412ddbc3cbc4f |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ace72eb82a04499ab63412ddbc3cbc4f2025-08-20T02:57:17ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802025-01-01190110.3855/jidc.19228Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysisChaoxin Chen0Tingting Chen1Dan Xue2Maobai Liu3Bin Zheng4Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, ChinaDepartment of Pharmacy, Fujian Obstetrics and Gynecology Hospital, Fuzhou, ChinaDepartment of Respiratory, Fujian Medical University Union Hospital, Fuzhou, ChinaDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, ChinaDepartment of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China Introduction: A pharmacoeconomic analysis model was developed to evaluate the cost-effectiveness of antibiotics from a societal perspective in Korea and China. A network meta-analysis was conducted to evaluate the efficacy of antibiotics. Methodology: We conducted a systematic search for randomized controlled trials or quasi-randomized controlled trials on antibiotics employed as therapy in scrub typhus management. We performed a network meta-analysis to obtain their relative efficacy. The outcome measures for efficacy were cure rate and non-relapse rate. To evaluate their relative cost-effectiveness in Korea and China, a decision analytic model simulating a cohort of scrub typhus patients using antibiotics as therapy was constructed from a societal perspective over 8 weeks. The number of cure cases per 1000 patients and the incremental cost-effectiveness ratio (ICER) was calculated. Results: We identified 11 relevant articles for network meta-analysis. Of the seven comparisons (azithromycin, chloramphenicol, doxycycline, high-dose rifampin, low-dose rifampin, telithromycin, tetracycline) included in the network meta-analysis, tetracycline was the most effective drug for the treatment of scrub typhus, but the difference is not significant. In the cost-effectiveness analysis, all the treatments were dominated by tetracycline in Korea and China. Conclusions: Tetracycline is the most economic drug for the treatment of scrub typhus. Hence, tetracycline is recommended as the first choice for the treatment of scrub typhus without contraindications in China and Korea. https://jidc.org/index.php/journal/article/view/19228Scrub typhusnetwork meta-analysiscost-effectiveness analysisdecision analytic modelantibiotics |
| spellingShingle | Chaoxin Chen Tingting Chen Dan Xue Maobai Liu Bin Zheng Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis Journal of Infection in Developing Countries Scrub typhus network meta-analysis cost-effectiveness analysis decision analytic model antibiotics |
| title | Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis |
| title_full | Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis |
| title_fullStr | Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis |
| title_full_unstemmed | Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis |
| title_short | Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis |
| title_sort | antibiotics in the treatment of scrub typhus a network meta analysis and cost effectiveness analysis |
| topic | Scrub typhus network meta-analysis cost-effectiveness analysis decision analytic model antibiotics |
| url | https://jidc.org/index.php/journal/article/view/19228 |
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