Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite Biomaterial
Polyhydroxybutyrate (PHB) is widely used as a biomaterial in medical and tissue-engineering applications, a relatively high crystallinity limits its application. Blending PHB with ethyl-cellulose (EtC) was readily achieved to reduce PHB crystallinity and promote its degradation under physiological c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2011/651549 |
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| author | Rodman T. H. Chan Christopher J. Garvey Helder Marçal Robert A. Russell Peter J. Holden L. John R. Foster |
| author_facet | Rodman T. H. Chan Christopher J. Garvey Helder Marçal Robert A. Russell Peter J. Holden L. John R. Foster |
| author_sort | Rodman T. H. Chan |
| collection | DOAJ |
| description | Polyhydroxybutyrate (PHB) is widely used as a biomaterial in medical and tissue-engineering applications, a relatively high crystallinity limits its application. Blending PHB with ethyl-cellulose (EtC) was readily achieved to reduce PHB crystallinity and promote its degradation under physiological conditions without undue influence on biocompatibility. Material strength of composite films remained unchanged at 6.5 ± 0.6 MPa with 40% (w/w) EtC loadings. Phase separation between the two biopolymers was determined with PHB crystallinity decreasing from 63% to 47% for films with the same loading. This reduction in crystallinity supported an increase in the degradation rates of composite films from 0.39 to 0.81% wk−1 for PHB and its composite, respectively. No significant change in morphology and proliferation of olfactory ensheathing cells were observed with the composites despite significant increases in average surface roughness (Ra) of the films from 2.90 to 3.65 μm for PHB and blends with 80% (w/w) EtC, respectively. |
| format | Article |
| id | doaj-art-ace39a58650748d7beecf954d6d66d13 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-ace39a58650748d7beecf954d6d66d132025-02-03T05:43:45ZengWileyInternational Journal of Polymer Science1687-94221687-94302011-01-01201110.1155/2011/651549651549Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite BiomaterialRodman T. H. Chan0Christopher J. Garvey1Helder Marçal2Robert A. Russell3Peter J. Holden4L. John R. Foster5Bio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, NSW 2052, AustraliaAustralian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, AustraliaBio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, NSW 2052, AustraliaBio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, NSW 2052, AustraliaAustralian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, AustraliaBio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, NSW 2052, AustraliaPolyhydroxybutyrate (PHB) is widely used as a biomaterial in medical and tissue-engineering applications, a relatively high crystallinity limits its application. Blending PHB with ethyl-cellulose (EtC) was readily achieved to reduce PHB crystallinity and promote its degradation under physiological conditions without undue influence on biocompatibility. Material strength of composite films remained unchanged at 6.5 ± 0.6 MPa with 40% (w/w) EtC loadings. Phase separation between the two biopolymers was determined with PHB crystallinity decreasing from 63% to 47% for films with the same loading. This reduction in crystallinity supported an increase in the degradation rates of composite films from 0.39 to 0.81% wk−1 for PHB and its composite, respectively. No significant change in morphology and proliferation of olfactory ensheathing cells were observed with the composites despite significant increases in average surface roughness (Ra) of the films from 2.90 to 3.65 μm for PHB and blends with 80% (w/w) EtC, respectively.http://dx.doi.org/10.1155/2011/651549 |
| spellingShingle | Rodman T. H. Chan Christopher J. Garvey Helder Marçal Robert A. Russell Peter J. Holden L. John R. Foster Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite Biomaterial International Journal of Polymer Science |
| title | Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite Biomaterial |
| title_full | Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite Biomaterial |
| title_fullStr | Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite Biomaterial |
| title_full_unstemmed | Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite Biomaterial |
| title_short | Manipulation of Polyhydroxybutyrate Properties through Blending with Ethyl-Cellulose for a Composite Biomaterial |
| title_sort | manipulation of polyhydroxybutyrate properties through blending with ethyl cellulose for a composite biomaterial |
| url | http://dx.doi.org/10.1155/2011/651549 |
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