Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational Study
Background: We analyzed both early and late (persistent) phases of each cytomegalovirus (CMV) antibody in mothers with primary CMV infection during pregnancy and subsequent congenital CMV infection for a long period from late pregnancy to after delivery using our stored serum samples. Methods: We us...
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| Format: | Article |
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IMR Press
2022-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/49/12/10.31083/j.ceog4912269 |
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| author | Kuniaki Toriyabe Asa Kitamura Miki Hagimoto-Akasaka Toshio Minematsu Hiroki Takeuchi Eiji Kondo Masamichi Kihira Fumihiro Morikawa Tomoaki Ikeda |
| author_facet | Kuniaki Toriyabe Asa Kitamura Miki Hagimoto-Akasaka Toshio Minematsu Hiroki Takeuchi Eiji Kondo Masamichi Kihira Fumihiro Morikawa Tomoaki Ikeda |
| author_sort | Kuniaki Toriyabe |
| collection | DOAJ |
| description | Background: We analyzed both early and late (persistent) phases of each cytomegalovirus (CMV) antibody in mothers with primary CMV infection during pregnancy and subsequent congenital CMV infection for a long period from late pregnancy to after delivery using our stored serum samples. Methods: We used stored serum samples obtained during pregnancy to after delivery from mothers with CMV immunoglobulin (Ig) G seroconversion and subsequent infant congenital CMV infection. CMV antibodies, including CMV IgG titer, IgM titer, and IgG avidity, were assessed using the Denka IgG assay, Denka IgM assay Ver.1 and Ver.2, and Enzygnost IgG assay and Denka IgG avidity assay, respectively. We analyzed the dynamics of each CMV antibody for a long period from late pregnancy to after delivery and correlations of each antibody, calculating Pearson’s correlation coefficients (R2). Results: We used 67 serum samples obtained from 12 included participants between 2013 and 2018. CMV IgG increased until 61 weeks and did not change significantly after. CMV IgM decreased until 52 weeks and did not change significantly after that in both assays. CMV IgG avidity increased until 64 weeks and did not change significantly after that in both assays. In CMV IgM, a strong positive correlation was found (R2 = 0.9326) between the two different IgM assays. Serum results of the late phase (after 60 weeks) were subsumed into the area of high CMV IgG avidity and low CMV IgM titer, which probably was equivalent to the persistent IgM. Conclusions: CMV antibodies in mothers during the late phase of primary infection were in high IgG avidity and low IgM titer, which probably was equivalent to the persistent IgM. |
| format | Article |
| id | doaj-art-ace36a5510e1429fadd9b18392c0fa2c |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-ace36a5510e1429fadd9b18392c0fa2c2025-08-20T03:49:16ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-12-01491226910.31083/j.ceog4912269S0390-6663(22)01943-1Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational StudyKuniaki Toriyabe0Asa Kitamura1Miki Hagimoto-Akasaka2Toshio Minematsu3Hiroki Takeuchi4Eiji Kondo5Masamichi Kihira6Fumihiro Morikawa7Tomoaki Ikeda8Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 514-8507 Tsu, Mie, JapanDepartment of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 514-8507 Tsu, Mie, JapanDepartment of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 514-8507 Tsu, Mie, JapanResearch Center for Disease Control, Aisenkai Nichinan Hospital, 887-0034 Nichinan, Miyazaki, JapanDepartment of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 514-8507 Tsu, Mie, JapanDepartment of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 514-8507 Tsu, Mie, JapanMie Association of Obstetricians and Gynecologists, 514-0003 Tsu, Mie, JapanMie Association of Obstetricians and Gynecologists, 514-0003 Tsu, Mie, JapanDepartment of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 514-8507 Tsu, Mie, JapanBackground: We analyzed both early and late (persistent) phases of each cytomegalovirus (CMV) antibody in mothers with primary CMV infection during pregnancy and subsequent congenital CMV infection for a long period from late pregnancy to after delivery using our stored serum samples. Methods: We used stored serum samples obtained during pregnancy to after delivery from mothers with CMV immunoglobulin (Ig) G seroconversion and subsequent infant congenital CMV infection. CMV antibodies, including CMV IgG titer, IgM titer, and IgG avidity, were assessed using the Denka IgG assay, Denka IgM assay Ver.1 and Ver.2, and Enzygnost IgG assay and Denka IgG avidity assay, respectively. We analyzed the dynamics of each CMV antibody for a long period from late pregnancy to after delivery and correlations of each antibody, calculating Pearson’s correlation coefficients (R2). Results: We used 67 serum samples obtained from 12 included participants between 2013 and 2018. CMV IgG increased until 61 weeks and did not change significantly after. CMV IgM decreased until 52 weeks and did not change significantly after that in both assays. CMV IgG avidity increased until 64 weeks and did not change significantly after that in both assays. In CMV IgM, a strong positive correlation was found (R2 = 0.9326) between the two different IgM assays. Serum results of the late phase (after 60 weeks) were subsumed into the area of high CMV IgG avidity and low CMV IgM titer, which probably was equivalent to the persistent IgM. Conclusions: CMV antibodies in mothers during the late phase of primary infection were in high IgG avidity and low IgM titer, which probably was equivalent to the persistent IgM.https://www.imrpress.com/journal/CEOG/49/12/10.31083/j.ceog4912269cytomegaloviruspregnancyserumimmunoglobulin |
| spellingShingle | Kuniaki Toriyabe Asa Kitamura Miki Hagimoto-Akasaka Toshio Minematsu Hiroki Takeuchi Eiji Kondo Masamichi Kihira Fumihiro Morikawa Tomoaki Ikeda Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational Study Clinical and Experimental Obstetrics & Gynecology cytomegalovirus pregnancy serum immunoglobulin |
| title | Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational Study |
| title_full | Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational Study |
| title_fullStr | Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational Study |
| title_full_unstemmed | Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational Study |
| title_short | Maternal Cytomegalovirus Antibodies during Early and Late (Persistent) Phases after Primary Cytomegalovirus Infection during Pregnancy: An Observational Study |
| title_sort | maternal cytomegalovirus antibodies during early and late persistent phases after primary cytomegalovirus infection during pregnancy an observational study |
| topic | cytomegalovirus pregnancy serum immunoglobulin |
| url | https://www.imrpress.com/journal/CEOG/49/12/10.31083/j.ceog4912269 |
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