Impaired airway epithelial miR-155/BACH1/NRF2 axis and hypoxia gene expression during RSV infection in children with down syndrome

Impaired airway epithelial miR-155/BACH1/NRF2 axis and hypoxia gene expression during RSV infection in children with down syndrome

BackgroundChildren with Down Syndrome (DS) are at high risk for severe respiratory syncytial virus (RSV) infections. DS is associated with impaired cellular responses to oxidative stress and hypoxia; however, these abnormalities have not been explored in trisomy 21 (TS21) airway epithelial cells (AE...

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Main Authors: Allison Welham, Elizabeth Chorvinsky, Surajit Bhattacharya, Kyle Salka, Betelehem Solomon Bera, Woudasie Admasu, Maria C. Straker, Maria J. Gutierrez, Jyoti K. Jaiswal, Gustavo Nino
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pediatrics
Subjects:
trisomy 21 (Down syndrome)
RSV (respiratory syncytial virus)
airway epithelia
miR-155
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1553571/full
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