The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease Patients
Introduction. Contrast Induced Nephropathy (CIN) after percutaneous coronary intervention (PCI) is common in stage 3 chronic kidney disease (CKD) patients. While there is no cure for CIN and some cases are fatal for the kidney or even life, it is preventable. Eventhough controversial, hydration and...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2016-09-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/22/19 |
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| author | Lydia D Simatupang Endang Susalit Ika Prasetya Wijaya |
| author_facet | Lydia D Simatupang Endang Susalit Ika Prasetya Wijaya |
| author_sort | Lydia D Simatupang |
| collection | DOAJ |
| description | Introduction. Contrast Induced Nephropathy (CIN) after percutaneous coronary intervention (PCI) is common in stage 3 chronic kidney disease (CKD) patients. While there is no cure for CIN and some cases are fatal for the kidney or even life, it is preventable. Eventhough controversial, hydration and N-Acetyl Cysteine (NAC) are modalities to prevent CIN. Not having a certain guideline to prevent CIN in Integrated Cardiac Services (ICS) Cipto Mangunkusumo Hospital for PCI patients generates interest to study it.
Methods. A prospective cohort is conducted to evaluate plasma creatinine before and 48 hours after PCI, meanwhile recording whom is given combined hydration and NAC and which not.
Results. 43,4% of stage 3 CKD patients are given hydration and NAC, and incidence of CIN occurred in 5.26% patients all belonging to the non hydration and NAC group. Attributable risk is 100% means CIN can be prevented with hydration and NAC.
Conclusions. Hydation and NAC is indicated to be protective against CIN in s tage 3 CKD patients undergoing PCI. |
| format | Article |
| id | doaj-art-acdb76c8b5e0434cb60d7142761d7f53 |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2016-09-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-acdb76c8b5e0434cb60d7142761d7f532025-08-20T02:01:09ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212016-09-0133125130http://dx.doi.org/10.7454/jpdi.v3i3.22The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease PatientsLydia D Simatupang0Endang Susalit1Ika Prasetya Wijaya2Rumah Sakit Siloam, JakartaDivisi Ginjal Hipertensi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo, Jakarta Indonesia Divisi Kardiologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo, Jakarta Indonesia Introduction. Contrast Induced Nephropathy (CIN) after percutaneous coronary intervention (PCI) is common in stage 3 chronic kidney disease (CKD) patients. While there is no cure for CIN and some cases are fatal for the kidney or even life, it is preventable. Eventhough controversial, hydration and N-Acetyl Cysteine (NAC) are modalities to prevent CIN. Not having a certain guideline to prevent CIN in Integrated Cardiac Services (ICS) Cipto Mangunkusumo Hospital for PCI patients generates interest to study it. Methods. A prospective cohort is conducted to evaluate plasma creatinine before and 48 hours after PCI, meanwhile recording whom is given combined hydration and NAC and which not. Results. 43,4% of stage 3 CKD patients are given hydration and NAC, and incidence of CIN occurred in 5.26% patients all belonging to the non hydration and NAC group. Attributable risk is 100% means CIN can be prevented with hydration and NAC. Conclusions. Hydation and NAC is indicated to be protective against CIN in s tage 3 CKD patients undergoing PCI.http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/22/19contrast induced nephropathyhydrationN-Acetyl Cysteinepercutaneous coronary intervention |
| spellingShingle | Lydia D Simatupang Endang Susalit Ika Prasetya Wijaya The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease Patients Jurnal Penyakit Dalam Indonesia contrast induced nephropathy hydration N-Acetyl Cysteine percutaneous coronary intervention |
| title | The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease Patients |
| title_full | The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease Patients |
| title_fullStr | The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease Patients |
| title_full_unstemmed | The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease Patients |
| title_short | The Role of Hydration and N-Acetyl Cysteine Combination in 48 Hours Contrast-Induced Nephropaty after Percutaneous Coronary Intervention in Stage Three Chronic Kidney Disease Patients |
| title_sort | role of hydration and n acetyl cysteine combination in 48 hours contrast induced nephropaty after percutaneous coronary intervention in stage three chronic kidney disease patients |
| topic | contrast induced nephropathy hydration N-Acetyl Cysteine percutaneous coronary intervention |
| url | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/22/19 |
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