Blood coagulation monitoring of patients with mechanical heart valve visiting Imam

Abstract Background The lacking proper regulation of International Normalized Ratio (INR) as the main problem in patients with mechanical valve replacement surgery poses the risk of thrombosis and embolism on the one hand and the risk of bleeding on the other. For this reason, the correct monitoring...

Full description

Saved in:
Bibliographic Details
Main Authors: Nafiseh Montazeri, Sajad Pourmehr, Arash Ziapour, Reza Heidari Moghadam
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Online Access:https://doi.org/10.1186/s13019-024-03188-7
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832594431788711936
author Nafiseh Montazeri
Sajad Pourmehr
Arash Ziapour
Reza Heidari Moghadam
author_facet Nafiseh Montazeri
Sajad Pourmehr
Arash Ziapour
Reza Heidari Moghadam
author_sort Nafiseh Montazeri
collection DOAJ
description Abstract Background The lacking proper regulation of International Normalized Ratio (INR) as the main problem in patients with mechanical valve replacement surgery poses the risk of thrombosis and embolism on the one hand and the risk of bleeding on the other. For this reason, the correct monitoring of INR via the Time in Therapeutic Range (TTR) is needed. The present study aimed to explore the blood coagulation monitoring of patients with mechanical heart valve in Imam Ali Hospital of Kermanshah in 2021. Method In the present cross-sectional study, the research population consisted of 139 patients, who underwent mechanical heart valve replacement. Information on patients’ demographic variables, health records, comorbidities, and medications was collected using a checklist. During the monthly follow-up, INR and thrombotic and bleeding events were recorded through calls made to patients. Then the TTR was estimated based on Rosendahl’s model and compared with the standard rate to test the relationship with hemorrhagic and thrombotic events in SPSS21. Results The mean and standard deviation of patients’ age was 58.25 ± 10.16 years. Among 139 patients with mechanical heart valves, 55 (39.6%) were male and 84 (60.4%) were female. Ninety-one patients (65.5%) had primary-school education, 22 (15.8%) middle school education, 17 (12.2%) high school education and 9 (6.5%) had a university degree. Chi-square test results showed a positive and significant difference between the blood coagulation monitoring of patients with mechanical heart valves and sex, education, blood pressure, captopril drug and the number of visits and follow-up (p ≥ 0.05). Conclusion The present study showed that TTR was lower than normal in the target population. Therefore, it is necessary to closely monitor patients’ blood coagulation for the appropriate therapeutic dose according to patients’ sex, education, blood pressure, captopril drug and the number of visits and follow-up.
format Article
id doaj-art-acdb5801d5fe402596e84a3df068a8dc
institution Kabale University
issn 1749-8090
language English
publishDate 2025-01-01
publisher BMC
record_format Article
series Journal of Cardiothoracic Surgery
spelling doaj-art-acdb5801d5fe402596e84a3df068a8dc2025-01-19T12:38:15ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011810.1186/s13019-024-03188-7Blood coagulation monitoring of patients with mechanical heart valve visiting ImamNafiseh Montazeri0Sajad Pourmehr1Arash Ziapour2Reza Heidari Moghadam3Cardiovascular Research Center, Health Policy and Promotion Institute, Imam-Ali Hospital, Kermanshah University of Medical SciencesCardiovascular Research Center, Health Policy and Promotion Institute, Imam-Ali Hospital, Kermanshah University of Medical SciencesCardiovascular Research Center, Health Policy and Promotion Institute, Imam-Ali Hospital, Kermanshah University of Medical SciencesCardiovascular Research Center, Health Policy and Promotion Institute, Imam-Ali Hospital, Kermanshah University of Medical SciencesAbstract Background The lacking proper regulation of International Normalized Ratio (INR) as the main problem in patients with mechanical valve replacement surgery poses the risk of thrombosis and embolism on the one hand and the risk of bleeding on the other. For this reason, the correct monitoring of INR via the Time in Therapeutic Range (TTR) is needed. The present study aimed to explore the blood coagulation monitoring of patients with mechanical heart valve in Imam Ali Hospital of Kermanshah in 2021. Method In the present cross-sectional study, the research population consisted of 139 patients, who underwent mechanical heart valve replacement. Information on patients’ demographic variables, health records, comorbidities, and medications was collected using a checklist. During the monthly follow-up, INR and thrombotic and bleeding events were recorded through calls made to patients. Then the TTR was estimated based on Rosendahl’s model and compared with the standard rate to test the relationship with hemorrhagic and thrombotic events in SPSS21. Results The mean and standard deviation of patients’ age was 58.25 ± 10.16 years. Among 139 patients with mechanical heart valves, 55 (39.6%) were male and 84 (60.4%) were female. Ninety-one patients (65.5%) had primary-school education, 22 (15.8%) middle school education, 17 (12.2%) high school education and 9 (6.5%) had a university degree. Chi-square test results showed a positive and significant difference between the blood coagulation monitoring of patients with mechanical heart valves and sex, education, blood pressure, captopril drug and the number of visits and follow-up (p ≥ 0.05). Conclusion The present study showed that TTR was lower than normal in the target population. Therefore, it is necessary to closely monitor patients’ blood coagulation for the appropriate therapeutic dose according to patients’ sex, education, blood pressure, captopril drug and the number of visits and follow-up.https://doi.org/10.1186/s13019-024-03188-7CoagulationMechanical valveTTR
spellingShingle Nafiseh Montazeri
Sajad Pourmehr
Arash Ziapour
Reza Heidari Moghadam
Blood coagulation monitoring of patients with mechanical heart valve visiting Imam
Journal of Cardiothoracic Surgery
Coagulation
Mechanical valve
TTR
title Blood coagulation monitoring of patients with mechanical heart valve visiting Imam
title_full Blood coagulation monitoring of patients with mechanical heart valve visiting Imam
title_fullStr Blood coagulation monitoring of patients with mechanical heart valve visiting Imam
title_full_unstemmed Blood coagulation monitoring of patients with mechanical heart valve visiting Imam
title_short Blood coagulation monitoring of patients with mechanical heart valve visiting Imam
title_sort blood coagulation monitoring of patients with mechanical heart valve visiting imam
topic Coagulation
Mechanical valve
TTR
url https://doi.org/10.1186/s13019-024-03188-7
work_keys_str_mv AT nafisehmontazeri bloodcoagulationmonitoringofpatientswithmechanicalheartvalvevisitingimam
AT sajadpourmehr bloodcoagulationmonitoringofpatientswithmechanicalheartvalvevisitingimam
AT arashziapour bloodcoagulationmonitoringofpatientswithmechanicalheartvalvevisitingimam
AT rezaheidarimoghadam bloodcoagulationmonitoringofpatientswithmechanicalheartvalvevisitingimam