Comparative analysis of first-generation epidermal growth factor receptor inhibitors combined with chemotherapy versus third-generation epidermal growth factor receptor inhibitors in the treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis

Comparative analysis of first-generation epidermal growth factor receptor inhibitors combined with chemotherapy versus third-generation epidermal growth factor receptor inhibitors in the treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis

BackgroundIn advanced non-small cell lung cancer with EGFR mutations, third-generation EGFR TKIs (3rd-G TKIs) are currently the preferred first-line treatment. Previous studies have demonstrated that combining first-generation EGFR TKIs with chemotherapy (1st-G TKIs + chemo) also significantly enhan...

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Bibliographic Details
Main Authors: Siyan Peng, Zhixin Yu, Honglin Zhu, Chuwen Liang, Huijuan Qiu, Shaodong Hong, Yixin Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
EGFR mutant
chemotherapy
targeted therapy
advanced non small cell lung cancer
combined therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1586332/full
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