Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study
BackgroundA key driver that leads to age-associated decline and chronic disease is mitochondrial dysfunction. Our previous work revealed strong community interest in the concept of mitochondrial fitness, which led to the development of a video-based science communication inte...
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| Format: | Article |
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JMIR Publications
2024-12-01
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| Series: | JMIR Formative Research |
| Online Access: | https://formative.jmir.org/2024/1/e64437 |
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| author | Cathy A Maxwell Brandon Grubbs Mary S Dietrich Jeffrey T Boon John Dunavan Kelly J Knickerbocker Maulik R Patel |
| author_facet | Cathy A Maxwell Brandon Grubbs Mary S Dietrich Jeffrey T Boon John Dunavan Kelly J Knickerbocker Maulik R Patel |
| author_sort | Cathy A Maxwell |
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BackgroundA key driver that leads to age-associated decline and chronic disease is mitochondrial dysfunction. Our previous work revealed strong community interest in the concept of mitochondrial fitness, which led to the development of a video-based science communication intervention to prompt behavior change in adults aged 50 years and older.
ObjectiveThis study aimed to conduct formative and summative evaluations of MitoFit, an instructional, biologically based communication intervention aimed at improving physical activity in older adults aged 50 years and older.
MethodsIn the phase-1 formative evaluation, community-dwelling older adults (N=101) rated the acceptability, appropriateness, and helpfulness of our MitoFit video series, titled “How to Slow Down Aging Through Mitochondrial Fitness.” In the phase-2 summative evaluation, a subgroup of phase-1 participants (n=19) participated in a 1-month MitoFit intervention prototype to evaluate the intervention and data collection feasibility.
ResultsIn phase 1, participants (mean age 67.8, SD 8.9 y; 75/100, 75% female) rated the MitoFit videos as acceptable (≥4 out of 5 on a Likert-scale survey; from 97/101, 96% to 100/101, 99%), appropriate (101/101, 100%), and helpful (from 95/101, 94% to 100/101, 99%) to support adaptation and continued work on our novel approach. Previous knowledge of mitochondria ranged from 52% (50/97; What are mitochondria?) to 80% (78/97; What are the primary functions of mitochondria?). In phase 2, participants (mean age 71.4, SD 7.9 y; 13/19, 72% female) scored better than the national average (50) on the Patient-Reported Outcomes Measurement Information System-19 for physical function (57), social activities (55.5), depression (41), fatigue (48.6), and sleep disturbance (49.6) but worse for anxiety (55.3) and pain interference (52.4). Additionally, 95% (18/19) of participants demonstrated MitoFit competencies within 2 attempts (obtaining pulse: 19/19, 100%; calculating maximum and zone 2 heart rate: 18/19, 95%; and demonstration of exercises: 19/19, 100%). At 1 month after instruction, 68% (13/19) had completed a self-initiated daily walking/exercise plan and submitted a daily activity log. A walking pulse was documented by 85% (11/13) of participants. The time needed to walk 1 mile ranged from 17.4 to 27.1 minutes. The number of miles walked in 1 month was documented by 62% (8/13) of participants and ranged from 10 miles to 31 miles. The number of days of strength training ranged from 2 to 31 days/month. Intervention feasibility scores ranged from 89% (17/19; seems easy to follow) to 95% (18/19; seems implementable, possible, and doable). Overall, 79% (15/19) stated an intention to continue the MitoFit intervention. Furthermore, 4 weeks after delivery of the prototype intervention, the percentage of participants doing aerobic activity for regular moderate activity increased from 35% (6/17) to 59% (10/17; P=.03).
ConclusionsMitoFit was enthusiastically embraced and is a cost-effective, scalable, and potentially efficacious intervention to advance with community-dwelling older adults. |
| format | Article |
| id | doaj-art-acd5cb94f5f54d829b7ff20f32505d45 |
| institution | Kabale University |
| issn | 2561-326X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Formative Research |
| spelling | doaj-art-acd5cb94f5f54d829b7ff20f32505d452024-12-13T20:00:48ZengJMIR PublicationsJMIR Formative Research2561-326X2024-12-018e6443710.2196/64437Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot StudyCathy A Maxwellhttps://orcid.org/0000-0003-1980-8643Brandon Grubbshttps://orcid.org/0000-0001-9023-9688Mary S Dietrichhttps://orcid.org/0000-0003-4474-0767Jeffrey T Boonhttps://orcid.org/0009-0003-7790-7153John Dunavanhttps://orcid.org/0009-0007-9529-3406Kelly J Knickerbockerhttps://orcid.org/0009-0003-0588-0449Maulik R Patelhttps://orcid.org/0000-0003-3749-0122 BackgroundA key driver that leads to age-associated decline and chronic disease is mitochondrial dysfunction. Our previous work revealed strong community interest in the concept of mitochondrial fitness, which led to the development of a video-based science communication intervention to prompt behavior change in adults aged 50 years and older. ObjectiveThis study aimed to conduct formative and summative evaluations of MitoFit, an instructional, biologically based communication intervention aimed at improving physical activity in older adults aged 50 years and older. MethodsIn the phase-1 formative evaluation, community-dwelling older adults (N=101) rated the acceptability, appropriateness, and helpfulness of our MitoFit video series, titled “How to Slow Down Aging Through Mitochondrial Fitness.” In the phase-2 summative evaluation, a subgroup of phase-1 participants (n=19) participated in a 1-month MitoFit intervention prototype to evaluate the intervention and data collection feasibility. ResultsIn phase 1, participants (mean age 67.8, SD 8.9 y; 75/100, 75% female) rated the MitoFit videos as acceptable (≥4 out of 5 on a Likert-scale survey; from 97/101, 96% to 100/101, 99%), appropriate (101/101, 100%), and helpful (from 95/101, 94% to 100/101, 99%) to support adaptation and continued work on our novel approach. Previous knowledge of mitochondria ranged from 52% (50/97; What are mitochondria?) to 80% (78/97; What are the primary functions of mitochondria?). In phase 2, participants (mean age 71.4, SD 7.9 y; 13/19, 72% female) scored better than the national average (50) on the Patient-Reported Outcomes Measurement Information System-19 for physical function (57), social activities (55.5), depression (41), fatigue (48.6), and sleep disturbance (49.6) but worse for anxiety (55.3) and pain interference (52.4). Additionally, 95% (18/19) of participants demonstrated MitoFit competencies within 2 attempts (obtaining pulse: 19/19, 100%; calculating maximum and zone 2 heart rate: 18/19, 95%; and demonstration of exercises: 19/19, 100%). At 1 month after instruction, 68% (13/19) had completed a self-initiated daily walking/exercise plan and submitted a daily activity log. A walking pulse was documented by 85% (11/13) of participants. The time needed to walk 1 mile ranged from 17.4 to 27.1 minutes. The number of miles walked in 1 month was documented by 62% (8/13) of participants and ranged from 10 miles to 31 miles. The number of days of strength training ranged from 2 to 31 days/month. Intervention feasibility scores ranged from 89% (17/19; seems easy to follow) to 95% (18/19; seems implementable, possible, and doable). Overall, 79% (15/19) stated an intention to continue the MitoFit intervention. Furthermore, 4 weeks after delivery of the prototype intervention, the percentage of participants doing aerobic activity for regular moderate activity increased from 35% (6/17) to 59% (10/17; P=.03). ConclusionsMitoFit was enthusiastically embraced and is a cost-effective, scalable, and potentially efficacious intervention to advance with community-dwelling older adults.https://formative.jmir.org/2024/1/e64437 |
| spellingShingle | Cathy A Maxwell Brandon Grubbs Mary S Dietrich Jeffrey T Boon John Dunavan Kelly J Knickerbocker Maulik R Patel Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study JMIR Formative Research |
| title | Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study |
| title_full | Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study |
| title_fullStr | Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study |
| title_full_unstemmed | Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study |
| title_short | Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study |
| title_sort | mitochondrial fitness science communication for aging adults prospective formative pilot study |
| url | https://formative.jmir.org/2024/1/e64437 |
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