The Killer <i>Saccharomyces cerevisiae</i> Toxin: From Origin to Biomedical Research
The <i>killer</i> systems of <i>S. cerevisiae</i> are defined by the co-infection of two viral agents, an M virus and a helper virus. Each <i>killer</i> toxin is determined by the type of M virus (ScV-M1, ScV-M2, ScV-M28, and ScV-Mlus), which encodes a specific to...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/12/12/2481 |
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| Summary: | The <i>killer</i> systems of <i>S. cerevisiae</i> are defined by the co-infection of two viral agents, an M virus and a helper virus. Each <i>killer</i> toxin is determined by the type of M virus (ScV-M1, ScV-M2, ScV-M28, and ScV-Mlus), which encodes a specific toxin (K1, K2, K28, and Klus). Since their discovery, interest in their potential use as antimicrobial agents has driven research into the mechanisms of action of these toxins on susceptible cells. This review provides an overview of the key aspects of <i>killer</i> toxins, including their origin and the evolutionary implications surrounding the viruses involved in the <i>killer</i> system, as well as their potential applications in the biomedical field and as a biological control strategy. Special attention is given to the mechanisms of action described to date for the various <i>S. cerevisiae killer</i> toxins. |
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| ISSN: | 2076-2607 |