Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer

Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer

Approximately 70–80% of breast cancers rely on estrogen receptor alpha (ERα) for growth. The unfolded protein response (UPR), a cellular response to endoplasmic reticulum stress (ERS), is an important process crucial for oncogenic transformation. The effect of ERS on ERα expression and signaling rem...

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Bibliographic Details
Main Authors: Yuanli Wu, Gang Wang, Ruixue Yang, Duanfang Zhou, Qingjuan Chen, Qiuya Wu, Bo Chen, Lie Yuan, Na Qu, Hongmei Wang, Moustapha Hassan, Ying Zhao, Mingpu Liu, Zhengze Shen, Weiying Zhou
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Breast cancer
ESR1
ERα
Endoplasmic reticulum stress
Unfolded protein response
ATF4
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000442
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