Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies
Peri-implantitis (PI) presents a growing challenge in implant dentistry, with regenerative surgical approaches often incorporating barrier membranes despite the uncertainty of their clinical value. This systematic review and meta-analysis of in vivo studies aimed to evaluate the efficacy of barrier...
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MDPI AG
2025-07-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/7/262 |
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| author | Young Joon Cho Yong Tak Jeong Hyun Nyun Woo Hyun Woo Cho Min Gu Kang Sung-Min Hwang Jae-Mok Lee |
| author_facet | Young Joon Cho Yong Tak Jeong Hyun Nyun Woo Hyun Woo Cho Min Gu Kang Sung-Min Hwang Jae-Mok Lee |
| author_sort | Young Joon Cho |
| collection | DOAJ |
| description | Peri-implantitis (PI) presents a growing challenge in implant dentistry, with regenerative surgical approaches often incorporating barrier membranes despite the uncertainty of their clinical value. This systematic review and meta-analysis of in vivo studies aimed to evaluate the efficacy of barrier membranes in the reconstructive surgical treatment of PI. A comprehensive electronic search was performed in PubMed, Scopus, Google Scholar, and the Cochrane Library, covering studies published from 1990 to 2024. The protocol followed PRISMA guidelines and was registered in PROSPERO (CRD42025625417). Eligible studies included in vivo investigations comparing regenerative procedures with and without membrane use, with a minimum follow-up of 6 months and at least 10 implants per study. Risk of bias (RoB) was assessed using the Cochrane RoB tool. The meta-analysis was conducted using a random-effects model and included 15 studies comprising 560 patients. Although not consistently statistically significant, the findings suggested that membrane use may offer enhanced outcomes in terms of probing pocket depth (PPD) reduction and marginal bone level (MLB) gain. The evidence was limited by high clinical heterogeneity, variability in outcome definitions, and short follow-up durations. While membranes are commonly utilized, current evidence does not justify their routine use. Further well-designed, long-term clinical trials are needed to establish specific indications and optimize treatment strategies. |
| format | Article |
| id | doaj-art-acd18bd6ae9b4b53a529fb25e6800aca |
| institution | DOAJ |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-acd18bd6ae9b4b53a529fb25e6800aca2025-08-20T02:45:39ZengMDPI AGJournal of Functional Biomaterials2079-49832025-07-0116726210.3390/jfb16070262Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo StudiesYoung Joon Cho0Yong Tak Jeong1Hyun Nyun Woo2Hyun Woo Cho3Min Gu Kang4Sung-Min Hwang5Jae-Mok Lee6Mac Dental Clinic, Daegu 42117, Republic of KoreaMac Dental Clinic, Daegu 42117, Republic of KoreaPrivate Practice, New York, NY 10075, USADepartment of Oral & Maxillofacial Surgery, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118, USAPrivate Practice, Gumi-si 39236, Kyeongsangbuk-do, Republic of KoreaDepartment of Periodontology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of KoreaDepartment of Periodontology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of KoreaPeri-implantitis (PI) presents a growing challenge in implant dentistry, with regenerative surgical approaches often incorporating barrier membranes despite the uncertainty of their clinical value. This systematic review and meta-analysis of in vivo studies aimed to evaluate the efficacy of barrier membranes in the reconstructive surgical treatment of PI. A comprehensive electronic search was performed in PubMed, Scopus, Google Scholar, and the Cochrane Library, covering studies published from 1990 to 2024. The protocol followed PRISMA guidelines and was registered in PROSPERO (CRD42025625417). Eligible studies included in vivo investigations comparing regenerative procedures with and without membrane use, with a minimum follow-up of 6 months and at least 10 implants per study. Risk of bias (RoB) was assessed using the Cochrane RoB tool. The meta-analysis was conducted using a random-effects model and included 15 studies comprising 560 patients. Although not consistently statistically significant, the findings suggested that membrane use may offer enhanced outcomes in terms of probing pocket depth (PPD) reduction and marginal bone level (MLB) gain. The evidence was limited by high clinical heterogeneity, variability in outcome definitions, and short follow-up durations. While membranes are commonly utilized, current evidence does not justify their routine use. Further well-designed, long-term clinical trials are needed to establish specific indications and optimize treatment strategies.https://www.mdpi.com/2079-4983/16/7/262peri-implantitisdetoxificationguided bone regenerationresorbable membranesnon-resorbable membranesbone regeneration |
| spellingShingle | Young Joon Cho Yong Tak Jeong Hyun Nyun Woo Hyun Woo Cho Min Gu Kang Sung-Min Hwang Jae-Mok Lee Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies Journal of Functional Biomaterials peri-implantitis detoxification guided bone regeneration resorbable membranes non-resorbable membranes bone regeneration |
| title | Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies |
| title_full | Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies |
| title_fullStr | Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies |
| title_full_unstemmed | Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies |
| title_short | Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies |
| title_sort | reassessing the use of membranes in peri implantitis surgery a systematic review and meta analysis of in vivo studies |
| topic | peri-implantitis detoxification guided bone regeneration resorbable membranes non-resorbable membranes bone regeneration |
| url | https://www.mdpi.com/2079-4983/16/7/262 |
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