Phase I Study of the Anti-interleukin 33 Fragment Antigen-Binding Region RO7303359 in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Phase I Study of the Anti-interleukin 33 Fragment Antigen-Binding Region RO7303359 in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Purpose: Interleukin (IL) 33 is a potent proinflammatory cytokine and a potential target in age-related macular degeneration (AMD) pathophysiology. This study evaluated RO7303359, an anti–IL-33 fragment antigen-binding region (Fab) targeting the IL-33/serum stimulation-2 (ST2) pathway, in patients w...

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Main Authors: Joel A. Pearlman, MD, PhD, Veeral S. Sheth, MD, MBA, Arshad M. Khanani, MD, MA, Vahan B. Indjeian, PhD, Flavia Brunstein, MD, PhD, Denison Kuruvilla, PhD, Mauricio Maia, PhD, Randall Dere, Ling Ma, PhD, Hao Chen, PhD, Seema Datta, PhD, Jeffrey R. Willis, MD, PhD, Henry E. Wiley, MD
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ophthalmology Science
Subjects:
Clinical trial
Geographic atrophy
Interleukin 33 antigen binding fragment
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914525000983
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