An emerging role for neutrophils in the pathogenesis of endometriosis
Abstract Endometriosis is a chronic gynecological disease negatively impacting the health of women and is characterized by the presence of ectopic endometrial-like lesions. The immune system is implicated in endometriosis pathogenesis by promoting endometrial cell survival and creating a microenviro...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | npj Women's Health |
| Online Access: | https://doi.org/10.1038/s44294-025-00059-x |
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| author | Taylor R. Wilson Susan Kasper Katherine A. Burns |
| author_facet | Taylor R. Wilson Susan Kasper Katherine A. Burns |
| author_sort | Taylor R. Wilson |
| collection | DOAJ |
| description | Abstract Endometriosis is a chronic gynecological disease negatively impacting the health of women and is characterized by the presence of ectopic endometrial-like lesions. The immune system is implicated in endometriosis pathogenesis by promoting endometrial cell survival and creating a microenvironment for lesion development and growth. Neutrophils are phagocytic cells that degranulate, form neutrophil extracellular traps, and recruit immune cells to lesions. Herein we discuss the roles of neutrophils in endometriosis pathogenesis. |
| format | Article |
| id | doaj-art-acce9a0650014deaba56f805ca6216dd |
| institution | Kabale University |
| issn | 2948-1716 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Women's Health |
| spelling | doaj-art-acce9a0650014deaba56f805ca6216dd2025-02-09T13:00:35ZengNature Portfolionpj Women's Health2948-17162025-02-013111110.1038/s44294-025-00059-xAn emerging role for neutrophils in the pathogenesis of endometriosisTaylor R. Wilson0Susan Kasper1Katherine A. Burns2Division of Environmental Genetics and Molecular Toxicology, Department of Environmental and Public Health Sciences, University of Cincinnati, College of MedicineDivision of Environmental Genetics and Molecular Toxicology, Department of Environmental and Public Health Sciences, University of Cincinnati, College of MedicineDivision of Environmental Genetics and Molecular Toxicology, Department of Environmental and Public Health Sciences, University of Cincinnati, College of MedicineAbstract Endometriosis is a chronic gynecological disease negatively impacting the health of women and is characterized by the presence of ectopic endometrial-like lesions. The immune system is implicated in endometriosis pathogenesis by promoting endometrial cell survival and creating a microenvironment for lesion development and growth. Neutrophils are phagocytic cells that degranulate, form neutrophil extracellular traps, and recruit immune cells to lesions. Herein we discuss the roles of neutrophils in endometriosis pathogenesis.https://doi.org/10.1038/s44294-025-00059-x |
| spellingShingle | Taylor R. Wilson Susan Kasper Katherine A. Burns An emerging role for neutrophils in the pathogenesis of endometriosis npj Women's Health |
| title | An emerging role for neutrophils in the pathogenesis of endometriosis |
| title_full | An emerging role for neutrophils in the pathogenesis of endometriosis |
| title_fullStr | An emerging role for neutrophils in the pathogenesis of endometriosis |
| title_full_unstemmed | An emerging role for neutrophils in the pathogenesis of endometriosis |
| title_short | An emerging role for neutrophils in the pathogenesis of endometriosis |
| title_sort | emerging role for neutrophils in the pathogenesis of endometriosis |
| url | https://doi.org/10.1038/s44294-025-00059-x |
| work_keys_str_mv | AT taylorrwilson anemergingroleforneutrophilsinthepathogenesisofendometriosis AT susankasper anemergingroleforneutrophilsinthepathogenesisofendometriosis AT katherineaburns anemergingroleforneutrophilsinthepathogenesisofendometriosis AT taylorrwilson emergingroleforneutrophilsinthepathogenesisofendometriosis AT susankasper emergingroleforneutrophilsinthepathogenesisofendometriosis AT katherineaburns emergingroleforneutrophilsinthepathogenesisofendometriosis |