Oral health care knowledge among Phenylketonuria patients in the Latvian population
Background: Phenylketonuria (PKU) is an autosomal recessive inherited disorder of phenylalanine (Phe) metabolism that results from a deficiency of phenylalanine hydroxylase (PAH). Patients with PKU rely on amino acid mixtures and low-protein diets, which often exhibit an acidic nature and pose vario...
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Elsevier
2024-12-01
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| Series: | Molecular Genetics and Metabolism Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214426924001204 |
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| author | Iveta Abola Nikola Anna Intlere Anda Brinkmane Sabine Laktina Agnese Zarina Lauma Vasilevska Ingus Skadins Georgijs Moisejevs Linda Gailite Madara Auzenbaha |
| author_facet | Iveta Abola Nikola Anna Intlere Anda Brinkmane Sabine Laktina Agnese Zarina Lauma Vasilevska Ingus Skadins Georgijs Moisejevs Linda Gailite Madara Auzenbaha |
| author_sort | Iveta Abola |
| collection | DOAJ |
| description | Background: Phenylketonuria (PKU) is an autosomal recessive inherited disorder of phenylalanine (Phe) metabolism that results from a deficiency of phenylalanine hydroxylase (PAH). Patients with PKU rely on amino acid mixtures and low-protein diets, which often exhibit an acidic nature and pose various challenges to oral health. The objective of the study was to evaluate oral care habits of PKU patients in Latvia and the impact of the recommendations developed on improving oral care. Materials and methods: In this study, during a one-month interval before and after the implementation of oral hygiene recommendations, questionnaires were distributed to all patients with PKU diagnosed in Latvia, with a response rate of 78 % (79 of 101). Results: The group older and 18 years of age showed a poorer understanding of oral care even after receiving recommendations, 82 % brushing their teeth twice a day (92 % in the group <18 years of age), continuing 57 % rinsing their mouth after using amino acid formula (75 % in the younger group). Significant improvements were observed only in the respondent group younger than 18 years of age - including increases in toothbrushing twice a day by 25 % (p = 0.001), dental flossing by 23 % (p = 0.001), mouth rinsing after amino acid-based formula by 13 % (p = 0.020). Conclusion: This study concludes that PKU patients older and 18 years of age have a poor understanding of maintaining oral hygiene and the use of the necessary supplements to improve it. Activities are needed in the future that would regularly remind and motivate PKU patients to take care of their oral health. |
| format | Article |
| id | doaj-art-accda48c629a4bfdb47dd9c5242da498 |
| institution | OA Journals |
| issn | 2214-4269 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Genetics and Metabolism Reports |
| spelling | doaj-art-accda48c629a4bfdb47dd9c5242da4982025-08-20T01:58:23ZengElsevierMolecular Genetics and Metabolism Reports2214-42692024-12-014110116710.1016/j.ymgmr.2024.101167Oral health care knowledge among Phenylketonuria patients in the Latvian populationIveta Abola0Nikola Anna Intlere1Anda Brinkmane2Sabine Laktina3Agnese Zarina4Lauma Vasilevska5Ingus Skadins6Georgijs Moisejevs7Linda Gailite8Madara Auzenbaha9Department of Conservative Dentistry and Oral Health, Rīga Stradiņš University, LV-1007 Rīga, Latvia; Scientific Laboratory of Molecular Genetics, Rīga Stradiņš University, LV-1007 Rīga, Latvia; Corresponding author at: Department of Conservative Dentistry and Oral Health, Rīga Stradiņš University, LV-1007 Rīga, Latvia.Department of Conservative Dentistry and Oral Health, Rīga Stradiņš University, LV-1007 Rīga, LatviaDepartment of Conservative Dentistry and Oral Health, Rīga Stradiņš University, LV-1007 Rīga, LatviaClinic of Medical Genetics and Prenatal Diagnostics, Children's Clinical University Hospital, LV-1004 Rīga, LatviaClinic of Medical Genetics and Prenatal Diagnostics, Children's Clinical University Hospital, LV-1004 Rīga, Latvia; Department of Biology and Microbiology, Rīga Stradiņš University, LV-1007 Rīga, LatviaClinic of Medical Genetics and Prenatal Diagnostics, Children's Clinical University Hospital, LV-1004 Rīga, LatviaDepartment of Biology and Microbiology, Rīga Stradiņš University, LV-1007 Rīga, LatviaScientific Laboratory of Molecular Genetics, Rīga Stradiņš University, LV-1007 Rīga, Latvia; Jekabpils Regional Hospital, LV-5201, Jekabpils, LatviaScientific Laboratory of Molecular Genetics, Rīga Stradiņš University, LV-1007 Rīga, LatviaScientific Laboratory of Molecular Genetics, Rīga Stradiņš University, LV-1007 Rīga, Latvia; Clinic of Medical Genetics and Prenatal Diagnostics, Children's Clinical University Hospital, LV-1004 Rīga, Latvia; Department of Biology and Microbiology, Rīga Stradiņš University, LV-1007 Rīga, Latvia; European Reference Network for Rare Hereditary Metabolic Disorders, LatviaBackground: Phenylketonuria (PKU) is an autosomal recessive inherited disorder of phenylalanine (Phe) metabolism that results from a deficiency of phenylalanine hydroxylase (PAH). Patients with PKU rely on amino acid mixtures and low-protein diets, which often exhibit an acidic nature and pose various challenges to oral health. The objective of the study was to evaluate oral care habits of PKU patients in Latvia and the impact of the recommendations developed on improving oral care. Materials and methods: In this study, during a one-month interval before and after the implementation of oral hygiene recommendations, questionnaires were distributed to all patients with PKU diagnosed in Latvia, with a response rate of 78 % (79 of 101). Results: The group older and 18 years of age showed a poorer understanding of oral care even after receiving recommendations, 82 % brushing their teeth twice a day (92 % in the group <18 years of age), continuing 57 % rinsing their mouth after using amino acid formula (75 % in the younger group). Significant improvements were observed only in the respondent group younger than 18 years of age - including increases in toothbrushing twice a day by 25 % (p = 0.001), dental flossing by 23 % (p = 0.001), mouth rinsing after amino acid-based formula by 13 % (p = 0.020). Conclusion: This study concludes that PKU patients older and 18 years of age have a poor understanding of maintaining oral hygiene and the use of the necessary supplements to improve it. Activities are needed in the future that would regularly remind and motivate PKU patients to take care of their oral health.http://www.sciencedirect.com/science/article/pii/S2214426924001204Dental health educationDental statusOral healthPhenylketonuria |
| spellingShingle | Iveta Abola Nikola Anna Intlere Anda Brinkmane Sabine Laktina Agnese Zarina Lauma Vasilevska Ingus Skadins Georgijs Moisejevs Linda Gailite Madara Auzenbaha Oral health care knowledge among Phenylketonuria patients in the Latvian population Molecular Genetics and Metabolism Reports Dental health education Dental status Oral health Phenylketonuria |
| title | Oral health care knowledge among Phenylketonuria patients in the Latvian population |
| title_full | Oral health care knowledge among Phenylketonuria patients in the Latvian population |
| title_fullStr | Oral health care knowledge among Phenylketonuria patients in the Latvian population |
| title_full_unstemmed | Oral health care knowledge among Phenylketonuria patients in the Latvian population |
| title_short | Oral health care knowledge among Phenylketonuria patients in the Latvian population |
| title_sort | oral health care knowledge among phenylketonuria patients in the latvian population |
| topic | Dental health education Dental status Oral health Phenylketonuria |
| url | http://www.sciencedirect.com/science/article/pii/S2214426924001204 |
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