A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus
The pancreas belongs to the glands of mixed secretion and simultaneously performs both endo- and exocrine functions. Exocrine pancreatic insufficiency (EPI) is the general name for the malabsorption process caused by inadequate production and decreased activation of the enzymes of the pancreas acina...
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| Language: | English |
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Endocrinology Research Centre
2023-02-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12884 |
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| author | M. R. Ragimov T. V. Nikonova E. V. Marchenko N. M. Malysheva O. S. Derevyanko |
| author_facet | M. R. Ragimov T. V. Nikonova E. V. Marchenko N. M. Malysheva O. S. Derevyanko |
| author_sort | M. R. Ragimov |
| collection | DOAJ |
| description | The pancreas belongs to the glands of mixed secretion and simultaneously performs both endo- and exocrine functions. Exocrine pancreatic insufficiency (EPI) is the general name for the malabsorption process caused by inadequate production and decreased activation of the enzymes of the pancreas acinar cells, such as amylase, lipase and protease, which are necessary for digestion. The prevalence of EPI in patients with type 1 diabetes, according to many authors, varies from 25 to 59%, which is determine by the data of pancreatic elastase-1. In this work, we present a clinical case of confirmed exocrine pancreatic insufficiency in a patient with a 6-year history of type 1 diabetes, which became the main cause of the development of episodes of hypoglycemia after meals. In the course of further studies, antibodies to lactoferrin and a reduced prostate volume, determined by MRI data, high levels of antibodies to glutamate decarboxylase and zinc co-transporter 8, as well as residual insulin secretion based on the level of C-peptide on an empty stomach detected. |
| format | Article |
| id | doaj-art-acc9e73bbdeb4fdaa4c5dd10daa935e1 |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-acc9e73bbdeb4fdaa4c5dd10daa935e12025-08-20T02:29:39ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782023-02-01261939710.14341/DM1288410999A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitusM. R. Ragimov0T. V. Nikonova1E. V. Marchenko2N. M. Malysheva3O. S. Derevyanko4Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreThe pancreas belongs to the glands of mixed secretion and simultaneously performs both endo- and exocrine functions. Exocrine pancreatic insufficiency (EPI) is the general name for the malabsorption process caused by inadequate production and decreased activation of the enzymes of the pancreas acinar cells, such as amylase, lipase and protease, which are necessary for digestion. The prevalence of EPI in patients with type 1 diabetes, according to many authors, varies from 25 to 59%, which is determine by the data of pancreatic elastase-1. In this work, we present a clinical case of confirmed exocrine pancreatic insufficiency in a patient with a 6-year history of type 1 diabetes, which became the main cause of the development of episodes of hypoglycemia after meals. In the course of further studies, antibodies to lactoferrin and a reduced prostate volume, determined by MRI data, high levels of antibodies to glutamate decarboxylase and zinc co-transporter 8, as well as residual insulin secretion based on the level of C-peptide on an empty stomach detected.https://www.dia-endojournals.ru/jour/article/view/12884еxocrine pancreatic insufficiencytype 1 diabetes mellituspancreatic elastase-1 |
| spellingShingle | M. R. Ragimov T. V. Nikonova E. V. Marchenko N. M. Malysheva O. S. Derevyanko A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus Сахарный диабет еxocrine pancreatic insufficiency type 1 diabetes mellitus pancreatic elastase-1 |
| title | A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus |
| title_full | A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus |
| title_fullStr | A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus |
| title_full_unstemmed | A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus |
| title_short | A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus |
| title_sort | clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus |
| topic | еxocrine pancreatic insufficiency type 1 diabetes mellitus pancreatic elastase-1 |
| url | https://www.dia-endojournals.ru/jour/article/view/12884 |
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