Advantages of Extracellular Ubiquitin in Modulation of Immune Responses
T and B lymphocytes play a central role in protecting the human body from infectious pathogens but occasionally they can escape immune tolerance, become activated, and induce autoimmune diseases. All deregulated cellular processes are associated with improper functioning of the ubiquitin-proteasome...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4190390 |
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| _version_ | 1849397658083393536 |
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| author | Rusudan Sujashvili |
| author_facet | Rusudan Sujashvili |
| author_sort | Rusudan Sujashvili |
| collection | DOAJ |
| description | T and B lymphocytes play a central role in protecting the human body from infectious pathogens but occasionally they can escape immune tolerance, become activated, and induce autoimmune diseases. All deregulated cellular processes are associated with improper functioning of the ubiquitin-proteasome system (UPS) in eukaryotic cells. The role of ubiquitin in regulation of immune responses and in autoimmune diseases is only beginning to emerge. Ubiquitin is found in intra- and extracellular fluids and is involved in regulation of numerous cellular processes. Extracellular ubiquitin ascribed a role in lymphocyte differentiation. It regulates differentiation and maturation of hematopoietic cell lines. Ubiquitination is involved in initiation, propagation, and termination of immune responses. Disrupted ubiquitination can lead to autoimmunity. Recent observations showed that it can suppress immune response and prevent inflammation. Exogenous ubiquitin may provide good potential as a new tool for targeted therapy for immune mediated disorders of various etiologies. |
| format | Article |
| id | doaj-art-acc531beb7374e34aafe23e89807ee3b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-acc531beb7374e34aafe23e89807ee3b2025-08-20T03:38:55ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/41903904190390Advantages of Extracellular Ubiquitin in Modulation of Immune ResponsesRusudan Sujashvili0Department of Biophysics, I.Beritashvili Center of Experimental Biomedicine, 14 Gotua, 0160 Tbilisi, GeorgiaT and B lymphocytes play a central role in protecting the human body from infectious pathogens but occasionally they can escape immune tolerance, become activated, and induce autoimmune diseases. All deregulated cellular processes are associated with improper functioning of the ubiquitin-proteasome system (UPS) in eukaryotic cells. The role of ubiquitin in regulation of immune responses and in autoimmune diseases is only beginning to emerge. Ubiquitin is found in intra- and extracellular fluids and is involved in regulation of numerous cellular processes. Extracellular ubiquitin ascribed a role in lymphocyte differentiation. It regulates differentiation and maturation of hematopoietic cell lines. Ubiquitination is involved in initiation, propagation, and termination of immune responses. Disrupted ubiquitination can lead to autoimmunity. Recent observations showed that it can suppress immune response and prevent inflammation. Exogenous ubiquitin may provide good potential as a new tool for targeted therapy for immune mediated disorders of various etiologies.http://dx.doi.org/10.1155/2016/4190390 |
| spellingShingle | Rusudan Sujashvili Advantages of Extracellular Ubiquitin in Modulation of Immune Responses Mediators of Inflammation |
| title | Advantages of Extracellular Ubiquitin in Modulation of Immune Responses |
| title_full | Advantages of Extracellular Ubiquitin in Modulation of Immune Responses |
| title_fullStr | Advantages of Extracellular Ubiquitin in Modulation of Immune Responses |
| title_full_unstemmed | Advantages of Extracellular Ubiquitin in Modulation of Immune Responses |
| title_short | Advantages of Extracellular Ubiquitin in Modulation of Immune Responses |
| title_sort | advantages of extracellular ubiquitin in modulation of immune responses |
| url | http://dx.doi.org/10.1155/2016/4190390 |
| work_keys_str_mv | AT rusudansujashvili advantagesofextracellularubiquitininmodulationofimmuneresponses |