Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis
IntroductionInflammatory bowel disease (IBD) is a chronic, potentially carcinogenic condition with limited treatment options. Rutin may represent a novel approach to treating IBD. Our aim is to conduct a systematic review of rutin, summarize its preclinical effects, demonstrate its efficacy, and pro...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1539469/full |
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| author | Zhenkai Zou Fanglian Zhang Zhigang Pan Jinyao Xu Xuanyi Li Xiangjun Sun Xufeng Wang Feng Qin Abulikemu Abulizi Qian Chen Ruicheng Yan Ruicheng Yan |
| author_facet | Zhenkai Zou Fanglian Zhang Zhigang Pan Jinyao Xu Xuanyi Li Xiangjun Sun Xufeng Wang Feng Qin Abulikemu Abulizi Qian Chen Ruicheng Yan Ruicheng Yan |
| author_sort | Zhenkai Zou |
| collection | DOAJ |
| description | IntroductionInflammatory bowel disease (IBD) is a chronic, potentially carcinogenic condition with limited treatment options. Rutin may represent a novel approach to treating IBD. Our aim is to conduct a systematic review of rutin, summarize its preclinical effects, demonstrate its efficacy, and provide guidance for future research.MethodsTo systematically evaluate the effectiveness and feasibility of rutin in the treatment of inflammatory bowel disease (IBD) based on published experiments. A literature search up to 2023 on rutin’s effects in IBD was conducted using PubMed, Embase, and Web of Science. Three independent assessors ensured objectivity by selecting and evaluating study quality and extracting data. A meta-analysis was performed using Review Manager 5.3 and STATA 17.0, combining results for a robust evaluation of rutin’s efficacy in IBD treatment.ResultsThe meta-analysis includes nine animal studies with a total of 174 animals. The findings from these studies indicate that rutin has a significant positive impact on various indicators of intestinal disease caused by IBD. Key results include: reduced weight loss, lower disease activity index (DAI), decreased inflammatory markers, reduced oxidative stress markers, increased antioxidant defenses. Its mechanism of action involves anti-inflammatory, antioxidant, inhibition of inflammatory signaling pathways, barrier protection, inhibition of adaptive immune responses, restoration of intestinal permeability, and regulation of microbiota.DiscussionPreclinical evidence suggests that rutin can significantly alleviate the abnormal indicators of intestinal inflammation. In experiments, the performance of rutin in various indicators is very close to existing positive control drugs such as sulfasalazine and budesonide, with similar therapeutic effects. Taken together, this meta-analysis reveal that rutin has the potential to be a feasible drug for the treatment of IBD.Systematic Review RegistrationCRD42024519891. |
| format | Article |
| id | doaj-art-acc4196f6e0944be83d485afab6eaa0d |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-acc4196f6e0944be83d485afab6eaa0d2025-08-20T03:11:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15394691539469Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysisZhenkai Zou0Fanglian Zhang1Zhigang Pan2Jinyao Xu3Xuanyi Li4Xiangjun Sun5Xufeng Wang6Feng Qin7Abulikemu Abulizi8Qian Chen9Ruicheng Yan10Ruicheng Yan11The First Clinical Medical School, Hubei University of Chinese Medicine, Wuhan, ChinaGeneral Surgery Department of Honghu Hospital of Traditional Chinese Medicine, Hubei, Honghu, ChinaDepartment of Hepatobiliary Surgery, Affiliated Hospital of Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaThe First Clinical Medical School, Hubei University of Chinese Medicine, Wuhan, ChinaThe First Clinical Medical School, Hubei University of Chinese Medicine, Wuhan, ChinaDepartment of Gastrointestinal Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaDepartment of Gastrointestinal Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaDepartment of Gastrointestinal Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaDepartment of Gastrointestinal Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaDepartment of Gastrointestinal Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaThe First Clinical Medical School, Hubei University of Chinese Medicine, Wuhan, ChinaDepartment of Gastrointestinal Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaIntroductionInflammatory bowel disease (IBD) is a chronic, potentially carcinogenic condition with limited treatment options. Rutin may represent a novel approach to treating IBD. Our aim is to conduct a systematic review of rutin, summarize its preclinical effects, demonstrate its efficacy, and provide guidance for future research.MethodsTo systematically evaluate the effectiveness and feasibility of rutin in the treatment of inflammatory bowel disease (IBD) based on published experiments. A literature search up to 2023 on rutin’s effects in IBD was conducted using PubMed, Embase, and Web of Science. Three independent assessors ensured objectivity by selecting and evaluating study quality and extracting data. A meta-analysis was performed using Review Manager 5.3 and STATA 17.0, combining results for a robust evaluation of rutin’s efficacy in IBD treatment.ResultsThe meta-analysis includes nine animal studies with a total of 174 animals. The findings from these studies indicate that rutin has a significant positive impact on various indicators of intestinal disease caused by IBD. Key results include: reduced weight loss, lower disease activity index (DAI), decreased inflammatory markers, reduced oxidative stress markers, increased antioxidant defenses. Its mechanism of action involves anti-inflammatory, antioxidant, inhibition of inflammatory signaling pathways, barrier protection, inhibition of adaptive immune responses, restoration of intestinal permeability, and regulation of microbiota.DiscussionPreclinical evidence suggests that rutin can significantly alleviate the abnormal indicators of intestinal inflammation. In experiments, the performance of rutin in various indicators is very close to existing positive control drugs such as sulfasalazine and budesonide, with similar therapeutic effects. Taken together, this meta-analysis reveal that rutin has the potential to be a feasible drug for the treatment of IBD.Systematic Review RegistrationCRD42024519891.https://www.frontiersin.org/articles/10.3389/fphar.2025.1539469/fullinflammatory bowel diseaseIBDmeta-analysisrutinanti-inflammatory effects |
| spellingShingle | Zhenkai Zou Fanglian Zhang Zhigang Pan Jinyao Xu Xuanyi Li Xiangjun Sun Xufeng Wang Feng Qin Abulikemu Abulizi Qian Chen Ruicheng Yan Ruicheng Yan Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis Frontiers in Pharmacology inflammatory bowel disease IBD meta-analysis rutin anti-inflammatory effects |
| title | Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis |
| title_full | Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis |
| title_fullStr | Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis |
| title_full_unstemmed | Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis |
| title_short | Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis |
| title_sort | assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease a meta analysis |
| topic | inflammatory bowel disease IBD meta-analysis rutin anti-inflammatory effects |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1539469/full |
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