α-spinasterol isolated from Achyranthes aspera L. ameliorates inflammation via NF-κB and Nrf2/HO-1 pathways

α-spinasterol isolated from Achyranthes aspera L. ameliorates inflammation via NF-κB and Nrf2/HO-1 pathways

Abstract On the basis of previous studies, the low-polar part of Achyranthes aspera L. (A. aspera) had strong anti-inflammatory activity. Three compounds were isolated from the low polarity fraction of A. aspera, and their structures were identified as α-spinasterol (1), 7,8-dihydrospinasterol (2),...

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Bibliographic Details
Main Authors: Qiongli Zeng, Weiting Xiao, Heng Zhang, Wei Liu, Xionglong Wang, Zhen Li, Yue Han, Zhi Wang, Shunxiang Li, Jinwei Yang, Wen Ouyang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
α-Spinasterol
Content determination
NF-κB
Anti-inflammatory
Nrf2
Online Access:https://doi.org/10.1038/s41598-025-90022-2
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