Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse
Macrophages are highly plastic innate immune cells that adopt an important diversity of phenotypes in response to environmental cues. Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2790627 |
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| author | Marion Rolot Benjamin G. Dewals |
| author_facet | Marion Rolot Benjamin G. Dewals |
| author_sort | Marion Rolot |
| collection | DOAJ |
| description | Macrophages are highly plastic innate immune cells that adopt an important diversity of phenotypes in response to environmental cues. Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-13. Alternative activation of macrophages by IL-4 in vitro was described as an opposite phenotype of classically activated macrophages, but the in vivo reality is much more complex. Their exact activation state as well as the role of these cells and associated molecules in type 2 immune responses remains to be fully understood. We can take advantage of a variety of helminth models available, each of which have their own feature including life cycle, site of infection, or pathological mechanisms influencing macrophage biology. Here, we reviewed the recent advances from the laboratory mouse about macrophage origin, polarization, activation, and effector functions during parasitic helminth infection. |
| format | Article |
| id | doaj-art-acbd56a70e1f4edaa3f40e4b8b0fe7b3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-acbd56a70e1f4edaa3f40e4b8b0fe7b32025-08-20T03:38:55ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/27906272790627Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory MouseMarion Rolot0Benjamin G. Dewals1Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine-FARAH, University of Liège, Liège, BelgiumImmunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine-FARAH, University of Liège, Liège, BelgiumMacrophages are highly plastic innate immune cells that adopt an important diversity of phenotypes in response to environmental cues. Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-13. Alternative activation of macrophages by IL-4 in vitro was described as an opposite phenotype of classically activated macrophages, but the in vivo reality is much more complex. Their exact activation state as well as the role of these cells and associated molecules in type 2 immune responses remains to be fully understood. We can take advantage of a variety of helminth models available, each of which have their own feature including life cycle, site of infection, or pathological mechanisms influencing macrophage biology. Here, we reviewed the recent advances from the laboratory mouse about macrophage origin, polarization, activation, and effector functions during parasitic helminth infection.http://dx.doi.org/10.1155/2018/2790627 |
| spellingShingle | Marion Rolot Benjamin G. Dewals Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse Journal of Immunology Research |
| title | Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse |
| title_full | Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse |
| title_fullStr | Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse |
| title_full_unstemmed | Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse |
| title_short | Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse |
| title_sort | macrophage activation and functions during helminth infection recent advances from the laboratory mouse |
| url | http://dx.doi.org/10.1155/2018/2790627 |
| work_keys_str_mv | AT marionrolot macrophageactivationandfunctionsduringhelminthinfectionrecentadvancesfromthelaboratorymouse AT benjamingdewals macrophageactivationandfunctionsduringhelminthinfectionrecentadvancesfromthelaboratorymouse |