TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological Parameters
Background and objectives: Split genes that contain Transducin-Like Enhancer encode transcriptional corepressors that are essential for hematopoiesis and embryogenesis in humans. Synovial sarcomas express Transducin-Like Enhancer-1, a distinct factor which hardly has been shown in other soft tissue...
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Kurdistan Higher Council Of Medical Specialties
2024-09-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/492 |
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| author | Toqa Jabbar Chckaim Saman Salah Eldeen Abdulla Savan Saeed Azeez |
| author_facet | Toqa Jabbar Chckaim Saman Salah Eldeen Abdulla Savan Saeed Azeez |
| author_sort | Toqa Jabbar Chckaim |
| collection | DOAJ |
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Background and objectives: Split genes that contain Transducin-Like Enhancer encode transcriptional corepressors that are essential for hematopoiesis and embryogenesis in humans. Synovial sarcomas express Transducin-Like Enhancer-1, a distinct factor which hardly has been shown in other soft tissues malignancies. Transducin-Like Enhancer-1 expression was recently found to be sensitive but not entirely specific for synovial sarcoma.
Methods: This retrospective study included eighty paraffin embedded formalin-fixed blocks of different sarcomas which were gathered and picked out of the files of Rizgary teaching hospital lab and from certain private labs in Hawler, during June 2015-December 2022. In this study, Transducin-Like Enhancer-1, a mouse monoclonal antibody was applied on sarcoma cases and its expression was assessed.
Results: around one third (30%) of the patients had synovial sarcoma, (16.3%) had undifferentiated pleomorphic sarcoma, and the rest had other types. More than half (55%) of the sarcomas were of high grade, and the Transducin-Like Enhancer-1 score was strongly reactive in 33.8% of the patients. It was also strong in all (100%) the patients with synovial sarcoma, compared with 23.1% of patients with undifferentiated pleomorphic sarcoma, and 0% of the other types of sarcoma (p < 0.001).
Conclusion: this study demonstrates that, when synovial sarcoma was kept in the differential diagnosis of spindle cell soft tissue sarcomas, Transducin-Like Enhancer-1 was a highly sensitive and relatively a specific marker.
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| format | Article |
| id | doaj-art-acbbf77bf77e47cfbf09ff3567321499 |
| institution | DOAJ |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-acbbf77bf77e47cfbf09ff35673214992025-08-20T03:18:45ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802024-09-019310.56056/amj.2024.288493TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological ParametersToqa Jabbar Chckaim0Saman Salah Eldeen Abdulla1Savan Saeed Azeez2SHO of Histopathology, KBMS trainee in Rizgary Teaching Hospital, ErbilAss.Prof. Department of Basic Sciences/Pathology, College of Dentistry, Hawler Medical University, ErbilLecturer, Department of Anatomy and Pathology/Pathology, College of Medicine, Hawler Medical University, Erbil Background and objectives: Split genes that contain Transducin-Like Enhancer encode transcriptional corepressors that are essential for hematopoiesis and embryogenesis in humans. Synovial sarcomas express Transducin-Like Enhancer-1, a distinct factor which hardly has been shown in other soft tissues malignancies. Transducin-Like Enhancer-1 expression was recently found to be sensitive but not entirely specific for synovial sarcoma. Methods: This retrospective study included eighty paraffin embedded formalin-fixed blocks of different sarcomas which were gathered and picked out of the files of Rizgary teaching hospital lab and from certain private labs in Hawler, during June 2015-December 2022. In this study, Transducin-Like Enhancer-1, a mouse monoclonal antibody was applied on sarcoma cases and its expression was assessed. Results: around one third (30%) of the patients had synovial sarcoma, (16.3%) had undifferentiated pleomorphic sarcoma, and the rest had other types. More than half (55%) of the sarcomas were of high grade, and the Transducin-Like Enhancer-1 score was strongly reactive in 33.8% of the patients. It was also strong in all (100%) the patients with synovial sarcoma, compared with 23.1% of patients with undifferentiated pleomorphic sarcoma, and 0% of the other types of sarcoma (p < 0.001). Conclusion: this study demonstrates that, when synovial sarcoma was kept in the differential diagnosis of spindle cell soft tissue sarcomas, Transducin-Like Enhancer-1 was a highly sensitive and relatively a specific marker. https://amj.khcms.edu.krd/index.php/main/article/view/492ImmunohistochemistrySynovial sarcomaTLE1 |
| spellingShingle | Toqa Jabbar Chckaim Saman Salah Eldeen Abdulla Savan Saeed Azeez TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological Parameters Advanced Medical Journal Immunohistochemistry Synovial sarcoma TLE1 |
| title | TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological Parameters |
| title_full | TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological Parameters |
| title_fullStr | TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological Parameters |
| title_full_unstemmed | TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological Parameters |
| title_short | TLE1 Expression in Different Sarcoma Types and its Relation to Clinicopathological Parameters |
| title_sort | tle1 expression in different sarcoma types and its relation to clinicopathological parameters |
| topic | Immunohistochemistry Synovial sarcoma TLE1 |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/492 |
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