HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration
Abstract Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, largely because of its ability to reshape the tumor microenvironment and evade immune surveillance. Methods CX3CL1 expression in HCC tumor tissues was assessed via immunohistochemistry,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-025-02410-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850029788857630720 |
|---|---|
| author | Xiaoling Zhang Yidan Lou Song Zheng Xu Chang |
| author_facet | Xiaoling Zhang Yidan Lou Song Zheng Xu Chang |
| author_sort | Xiaoling Zhang |
| collection | DOAJ |
| description | Abstract Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, largely because of its ability to reshape the tumor microenvironment and evade immune surveillance. Methods CX3CL1 expression in HCC tumor tissues was assessed via immunohistochemistry, while plasma levels were quantified using enzyme-linked immunosorbent assays (ELISAs). CX3CR1-positive immune cell infiltration was analyzed by immunofluorescence. The associations among CX3CL1 expression, CX3CR1-positive cell infiltration, and patient prognosis were examined. Additionally, cell-based assays were conducted to evaluate the impact of CX3CL1 amplification on the expression of myeloid-derived suppressor cell (MDSC)-recruiting factors. Results Elevated CX3CL1 levels were significantly correlated with increased MDSC infiltration in the tumor microenvironment and poorer patient prognosis. CX3CL1 amplification led to the upregulation of MDSC-recruiting factors, suggesting a potential mechanism for immune evasion. Conclusions These findings highlight the possible involvement of CX3CL1 in HCC progression via MDSC recruitment, suggesting that it is a promising therapeutic target for promoting antitumor immunity. Further studies are needed to confirm these findings and explore potential therapeutic strategies. |
| format | Article |
| id | doaj-art-acb9a767e6944a3dabdaa3ce62356020 |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-acb9a767e6944a3dabdaa3ce623560202025-08-20T02:59:24ZengBMCEuropean Journal of Medical Research2047-783X2025-03-0130111010.1186/s40001-025-02410-zHCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltrationXiaoling Zhang0Yidan Lou1Song Zheng2Xu Chang3Department of Medical Oncology, Hangzhou First People’s HospitalDepartment of Medical Oncology, Hangzhou First People’s HospitalDepartment of Medical Oncology, Hangzhou First People’s HospitalDepartment of Interventional Therapy II, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical SciencesAbstract Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, largely because of its ability to reshape the tumor microenvironment and evade immune surveillance. Methods CX3CL1 expression in HCC tumor tissues was assessed via immunohistochemistry, while plasma levels were quantified using enzyme-linked immunosorbent assays (ELISAs). CX3CR1-positive immune cell infiltration was analyzed by immunofluorescence. The associations among CX3CL1 expression, CX3CR1-positive cell infiltration, and patient prognosis were examined. Additionally, cell-based assays were conducted to evaluate the impact of CX3CL1 amplification on the expression of myeloid-derived suppressor cell (MDSC)-recruiting factors. Results Elevated CX3CL1 levels were significantly correlated with increased MDSC infiltration in the tumor microenvironment and poorer patient prognosis. CX3CL1 amplification led to the upregulation of MDSC-recruiting factors, suggesting a potential mechanism for immune evasion. Conclusions These findings highlight the possible involvement of CX3CL1 in HCC progression via MDSC recruitment, suggesting that it is a promising therapeutic target for promoting antitumor immunity. Further studies are needed to confirm these findings and explore potential therapeutic strategies.https://doi.org/10.1186/s40001-025-02410-zCX3CL1HCCMDSCHepatocellular carcinomaCX3CR1 |
| spellingShingle | Xiaoling Zhang Yidan Lou Song Zheng Xu Chang HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration European Journal of Medical Research CX3CL1 HCC MDSC Hepatocellular carcinoma CX3CR1 |
| title | HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration |
| title_full | HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration |
| title_fullStr | HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration |
| title_full_unstemmed | HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration |
| title_short | HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration |
| title_sort | hcc derived cx3cl1 affects hepatocellular carcinoma prognosis and cx3cr1 mdsc infiltration |
| topic | CX3CL1 HCC MDSC Hepatocellular carcinoma CX3CR1 |
| url | https://doi.org/10.1186/s40001-025-02410-z |
| work_keys_str_mv | AT xiaolingzhang hccderivedcx3cl1affectshepatocellularcarcinomaprognosisandcx3cr1mdscinfiltration AT yidanlou hccderivedcx3cl1affectshepatocellularcarcinomaprognosisandcx3cr1mdscinfiltration AT songzheng hccderivedcx3cl1affectshepatocellularcarcinomaprognosisandcx3cr1mdscinfiltration AT xuchang hccderivedcx3cl1affectshepatocellularcarcinomaprognosisandcx3cr1mdscinfiltration |