Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice
Titanium dioxide nanoparticles (TiO2NPs) are excessively used and represent one of the top five most commonly used nanoparticles worldwide. Recently, various studies referred to their toxic potential on various organs using different treatment route. Male Swiss Webster mice were orally administrated...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/6710840 |
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| author | Hanan R. H. Mohamed Nahed A. Hussien |
| author_facet | Hanan R. H. Mohamed Nahed A. Hussien |
| author_sort | Hanan R. H. Mohamed |
| collection | DOAJ |
| description | Titanium dioxide nanoparticles (TiO2NPs) are excessively used and represent one of the top five most commonly used nanoparticles worldwide. Recently, various studies referred to their toxic potential on various organs using different treatment route. Male Swiss Webster mice were orally administrated TiO2NPs (500 mg/kg b.w.) daily for five consecutive days and then animals were sacrificed at 24 h, 7 days, or 14 days after the last treatment. The present results report that exposure to TiO2NPs produces mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner. Moreover, Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of the Alzheimer’s disease. Therefore, from these findings, the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence. |
| format | Article |
| id | doaj-art-acb990fd36504cdc92f88176e90a219b |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-acb990fd36504cdc92f88176e90a219b2025-02-03T06:00:07ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/67108406710840Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of MiceHanan R. H. Mohamed0Nahed A. Hussien1Zoology Department, Faculty of Science, Cairo University, Giza 12613, EgyptZoology Department, Faculty of Science, Cairo University, Giza 12613, EgyptTitanium dioxide nanoparticles (TiO2NPs) are excessively used and represent one of the top five most commonly used nanoparticles worldwide. Recently, various studies referred to their toxic potential on various organs using different treatment route. Male Swiss Webster mice were orally administrated TiO2NPs (500 mg/kg b.w.) daily for five consecutive days and then animals were sacrificed at 24 h, 7 days, or 14 days after the last treatment. The present results report that exposure to TiO2NPs produces mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner. Moreover, Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of the Alzheimer’s disease. Therefore, from these findings, the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.http://dx.doi.org/10.1155/2016/6710840 |
| spellingShingle | Hanan R. H. Mohamed Nahed A. Hussien Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice Scientifica |
| title | Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice |
| title_full | Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice |
| title_fullStr | Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice |
| title_full_unstemmed | Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice |
| title_short | Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice |
| title_sort | genotoxicity studies of titanium dioxide nanoparticles tio2nps in the brain of mice |
| url | http://dx.doi.org/10.1155/2016/6710840 |
| work_keys_str_mv | AT hananrhmohamed genotoxicitystudiesoftitaniumdioxidenanoparticlestio2npsinthebrainofmice AT nahedahussien genotoxicitystudiesoftitaniumdioxidenanoparticlestio2npsinthebrainofmice |