Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates
Abstract Intrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders. IDPs, including intrinsically disordered regions (IDRs)...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-025-02214-x |
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| author | Caolitao Qin Yun-Long Wang Jian Zheng Xiang-Bo Wan Xin-Juan Fan |
| author_facet | Caolitao Qin Yun-Long Wang Jian Zheng Xiang-Bo Wan Xin-Juan Fan |
| author_sort | Caolitao Qin |
| collection | DOAJ |
| description | Abstract Intrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders. IDPs, including intrinsically disordered regions (IDRs), were previously considered undruggable due to their lack of stable binding pockets. However, recent evidence indicates that targeting them can influence cellular processes. This review explores current strategies to target IDPs and biomolecular condensates, potential improvements, and the challenges and opportunities in this evolving field. |
| format | Article |
| id | doaj-art-acb6704c5e664dd486ebb2f760289e67 |
| institution | DOAJ |
| issn | 1741-7007 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-acb6704c5e664dd486ebb2f760289e672025-08-20T03:09:21ZengBMCBMC Biology1741-70072025-05-0123112110.1186/s12915-025-02214-xCurrent perspectives in drug targeting intrinsically disordered proteins and biomolecular condensatesCaolitao Qin0Yun-Long Wang1Jian Zheng2Xiang-Bo Wan3Xin-Juan Fan4Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Pathology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityAbstract Intrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders. IDPs, including intrinsically disordered regions (IDRs), were previously considered undruggable due to their lack of stable binding pockets. However, recent evidence indicates that targeting them can influence cellular processes. This review explores current strategies to target IDPs and biomolecular condensates, potential improvements, and the challenges and opportunities in this evolving field.https://doi.org/10.1186/s12915-025-02214-xIDPsBiomolecular condensatesDrug design |
| spellingShingle | Caolitao Qin Yun-Long Wang Jian Zheng Xiang-Bo Wan Xin-Juan Fan Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates BMC Biology IDPs Biomolecular condensates Drug design |
| title | Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates |
| title_full | Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates |
| title_fullStr | Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates |
| title_full_unstemmed | Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates |
| title_short | Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates |
| title_sort | current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates |
| topic | IDPs Biomolecular condensates Drug design |
| url | https://doi.org/10.1186/s12915-025-02214-x |
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