Sensing of endogenous retroviruses-derived RNA by ZBP1 triggers PANoptosis in DNA damage and contributes to toxic side effects of chemotherapy

Sensing of endogenous retroviruses-derived RNA by ZBP1 triggers PANoptosis in DNA damage and contributes to toxic side effects of chemotherapy

Abstract Excessive DNA damage triggers various types of programmed cell death (PCD), yet the regulatory mechanism of DNA damage-induced cell death is not fully understood. Here, we report that PANoptosis, a coordinated PCD pathway, including pyroptosis, apoptosis and necroptosis, is activated by DNA...

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Main Authors: Fang Wang, Kaiying Li, Wensheng Wang, Hui Jiang, Jiangping He, Jin Cai, Wenqing Ren, Yaxing Zhao, Qianqian Song, Yuan He, Yanlei Ma, Xiaona Feng, Yue Liu, Jianqiang Yu, Siriporn Jitkaew, Dan Ma, Zhenyu Cai
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07175-7
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