Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution Approach
Extended-spectrum cephalosporin-resistant <i>Escherichia coli</i> (ESC-EC) poses a significant public health concern, with its presence increasingly detected in healthy humans and various animal species. This study explores the transmission dynamic of ESC-EC within the Danish population...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Zoonotic Diseases |
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| Online Access: | https://www.mdpi.com/2813-0227/5/1/7 |
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| author | Maja Lykke Brinch Ana Sofia Ribeiro Duarte Ofosuhene O. Apenteng Tine Hald |
| author_facet | Maja Lykke Brinch Ana Sofia Ribeiro Duarte Ofosuhene O. Apenteng Tine Hald |
| author_sort | Maja Lykke Brinch |
| collection | DOAJ |
| description | Extended-spectrum cephalosporin-resistant <i>Escherichia coli</i> (ESC-EC) poses a significant public health concern, with its presence increasingly detected in healthy humans and various animal species. This study explores the transmission dynamic of ESC-EC within the Danish population as well as the transmission impact of a range of food and animal sources. We developed a compartmental model encompassing farmers, pet owners, and the general population. Additionally, we applied an established source attribution model to estimate the contributions to the transmission of different sources using Danish surveillance data on the distribution of resistance genes in <i>E. coli</i>. Our findings highlight the central role of human-to-human transmission while also showing the significant contributions of food and animal sources to the spread of ESC-EC in sporadic human infections. Imported food, pets, and livestock were estimated to contribute importantly to human infections. The results emphasize the complexity of ESC-EC transmission dynamics and the critical value of employing a One Health approach in modeling disease transmission and in the development of targeted intervention strategies. |
| format | Article |
| id | doaj-art-acb057da80954bdea895be39305a7704 |
| institution | OA Journals |
| issn | 2813-0227 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Zoonotic Diseases |
| spelling | doaj-art-acb057da80954bdea895be39305a77042025-08-20T01:49:57ZengMDPI AGZoonotic Diseases2813-02272025-03-0151710.3390/zoonoticdis5010007Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution ApproachMaja Lykke Brinch0Ana Sofia Ribeiro Duarte1Ofosuhene O. Apenteng2Tine Hald3National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, DenmarkNational Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, DenmarkSection of Animal Welfare and Disease Control, Department Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, DenmarkNational Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, DenmarkExtended-spectrum cephalosporin-resistant <i>Escherichia coli</i> (ESC-EC) poses a significant public health concern, with its presence increasingly detected in healthy humans and various animal species. This study explores the transmission dynamic of ESC-EC within the Danish population as well as the transmission impact of a range of food and animal sources. We developed a compartmental model encompassing farmers, pet owners, and the general population. Additionally, we applied an established source attribution model to estimate the contributions to the transmission of different sources using Danish surveillance data on the distribution of resistance genes in <i>E. coli</i>. Our findings highlight the central role of human-to-human transmission while also showing the significant contributions of food and animal sources to the spread of ESC-EC in sporadic human infections. Imported food, pets, and livestock were estimated to contribute importantly to human infections. The results emphasize the complexity of ESC-EC transmission dynamics and the critical value of employing a One Health approach in modeling disease transmission and in the development of targeted intervention strategies.https://www.mdpi.com/2813-0227/5/1/7antimicrobial resistancesource attributioncompartmental modelESC <i>E. coli</i> |
| spellingShingle | Maja Lykke Brinch Ana Sofia Ribeiro Duarte Ofosuhene O. Apenteng Tine Hald Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution Approach Zoonotic Diseases antimicrobial resistance source attribution compartmental model ESC <i>E. coli</i> |
| title | Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution Approach |
| title_full | Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution Approach |
| title_fullStr | Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution Approach |
| title_full_unstemmed | Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution Approach |
| title_short | Modeling the Transmission of ESBL and AmpC-Producing <i>Escherichia coli</i> in Denmark: A Compartmental and Source Attribution Approach |
| title_sort | modeling the transmission of esbl and ampc producing i escherichia coli i in denmark a compartmental and source attribution approach |
| topic | antimicrobial resistance source attribution compartmental model ESC <i>E. coli</i> |
| url | https://www.mdpi.com/2813-0227/5/1/7 |
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